Human NRG1-beta 1/HRG1-beta 1 DuoSet ELISA, 15 Plate

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The neuregulin (also known as heregulin) cytokine family is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. The NRG1 gene is the most pleiotropic, encoding more than 14 soluble or transmembrane proteins. NRG1 isoforms can be classified into type I (neu differentiation factor, NDF; heregulin, HRG; acetylcholine receptor inducing activity, ARIA), type II (glial growth factor, GGF) and type III (sensory and motor neuron-derived factor, SMDF) isoforms. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.

We have publications tested in 3 confirmed species: Human, Rat, Xenograft.

Showing Publications 1 - 10 of 20. Show All 20 Publications. Collapse Publications.

Publications using DY377	Applications	Species
Yun, JH;Hong, Y;Hong, MH;Kim, G;Lee, JS;Woo, RS;Lee, J;Yang, EJ;Kim, IS; Anti-inflammatory effects of neuregulin-1 in HaCaT keratinocytes and atopic dermatitis-like mice stimulated with Der p 38 Cytokine 2024-02-01 [PMID: 38134557] (Human)		Human
AK Podder, MA Mohamed, G Tseropoulo, B Nasiri, ST Andreadis Engineering Nanofiber Scaffolds with Biomimetic Cues for Differentiation of Skin-Derived Neural Crest-like Stem Cells to Schwann Cells International Journal of Molecular Sciences, 2022-09-16;23(18):. 2022-09-16 [PMID: 36142746] (Human)		Human
H Yang, W Pan, W Xiao, M Yang, J Xu, J Li, X Zhang Antipsychotic drugs increase Neuregulin1beta1 serum levels in first-episode drug-na�ve patients and chronic schizophrenia with suggestions for improving the treatment of psychotic symptoms BMC Psychiatry, 2022-03-25;22(1):217. 2022-03-25 [PMID: 35337293] (Human)		Human
DH Shin, SH Kim, M Choi, YK Bae, C Han, BK Choi, SS Kim, JY Han Oncogenic KRAS promotes growth of lung cancer cells expressing SLC3A2-NRG1 fusion via ADAM17-mediated shedding of NRG1 Oncogene, 2021-11-06;0(0):. 2021-11-06 [PMID: 34743207] (Human)		Human
F Mouton-Lig, J Dumurgier, E Cognat, C Hourregue, H Zetterberg, H Vanderstic, E Vanmechele, E Bouaziz-Am, K Blennow, J Hugon, C Paquet CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer's disease Alzheimers Res Ther, 2020-07-20;12(1):88. 2020-07-20 [PMID: 32690068] (Human)		Human
SJ Wang, R Li, TSC Ng, G Luthria, MJ Oudin, M Prytyskach, RH Kohler, R Weissleder, DA Lauffenbur, MA Miller Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy Sci Adv, 2020-05-22;6(21):eaaz8521. 2020-05-22 [PMID: 32494745] (Human)		Human
K Szu?drzy?s, M Jankowski, DP Potaczek, A Undas Plasma Fibrin Clot Properties as Determinants of Bleeding Time in Human Subjects: Association with Histidine-Rich Glycoprotein Dis. Markers, 2020-01-25;2020(0):7190828. 2020-01-25 [PMID: 32076463] (Human)		Human
S Ryu, JM Lee, CA Bae, CE Moon, KO Cho Therapeutic efficacy of neuregulin 1-expressing human adipose-derived mesenchymal stem cells for ischemic stroke PLoS ONE, 2019-09-27;14(9):e0222587. 2019-09-27 [PMID: 31560696] (Human, Xenograft)		Human, Xenograft
C Li, H Tao, X Yang, X Zhang, Y Liu, Y Tang, A Tang Assessment of a combination of Serum Proteins as potential biomarkers to clinically predict Schizophrenia Int J Med Sci, 2018-06-04;15(9):900-906. 2018-06-04 [PMID: 30008602] (Human)		Human
N Schwartz, M Pellach, Y Glick, R Gil, G Levy, D Avrahami, E Barbiro-Mi, Y Nahmias, D Gerber Neuregulin 1 discovered as a cleavage target for the HCV NS3/4A protease by a microfluidic membrane protein array N Biotechnol, 2018-02-10;0(0):. 2018-02-10 [PMID: 29438748] (Human)		Human
Y Miura, Y Sukawa, S Hironaka, M Mori, K Nishikawa, S Tokunaga, H Okuda, T Sakamoto, K Taku, K Nishikawa, T Moriwaki, Y Negoro, Y Kimura, K Uchino, K Shinozaki, H Shinozaki, N Musha, H Yoshiyama, T Tsuda, Y Miyata, N Sugimoto, T Shirakawa, M Ito, K Yonesaka, K Yoshimura, N Boku, K Nosho, T Takano, I Hyodo Five-weekly S-1 plus cisplatin therapy combined with trastuzumab therapy in HER2-positive gastric cancer: a phase II trial and biomarker study (WJOG7212G) Gastric Cancer, 2017-05-11;0(0):. 2017-05-11 [PMID: 28497176] (Human)		Human
Heregulin-1� and HER3 in hepatocellular carcinoma: status and regulation by insulin J Exp Clin Cancer Res, 2016-08-11;35(1):126. 2016-08-11 [PMID: 27514687] (Human)		Human
Patritumab plus trastuzumab and paclitaxel in human epidermal growth factor receptor 2-overexpressing metastatic breast cancer Cancer Sci., 2016-09-15;107(10):1465-1470. 2016-09-15 [PMID: 27452985] (Human)		Human
Gijsen M, King P, Perera T, Parker PJ, Harris AL, Larijani B, Kong A HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol., 2010-12-21;8(12):e1000563. 2010-12-21 [PMID: 21203579] (Human)		Human
Hickinson DM, Marshall GB, Beran GJ Identification of biomarkers in human head and neck tumor cell lines that predict for in vitro sensitivity to gefitinib. Clin Transl Sci, 2009-06-01;2(3):183-92. 2009-06-01 [PMID: 20443891] (Human)		Human
Calvo M, Zhu N, Tsantoulas C, Ma Z, Grist J, Loeb JA, Bennett DL Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury. J. Neurosci., 2010-04-14;30(15):5437-50. 2010-04-14 [PMID: 20392965] (Rat)		Rat
Hoffmann I, Bueter W, Zscheppang K, Brinkhaus MJ, Liese A, Riemke S, Dork T, Dammann O, Dammann CE Neuregulin-1, the fetal endothelium, and brain damage in preterm newborns. Brain Behav. Immun., 2009-09-04;24(5):784-91. 2009-09-04 [PMID: 19733651] (Human)		Human
Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, Arita S, Hongo S, Ota H, Kobayashi Y, Miyazaki A, Hirano T Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis. Circ. Res., 2009-07-30;105(5):500-10. 2009-07-30 [PMID: 19644050] (Human)		Human
Ky B, Kimmel SE, Safa RN, Putt ME, Sweitzer NK, Fang JC, Sawyer DB, Cappola TP Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure. Circulation, 2009-07-13;120(4):310-7. 2009-07-13 [PMID: 19597049] (Human)		Human
Zhou BB, Peyton M, He B, Liu C, Girard L, Caudler E, Lo Y, Baribaud F, Mikami I, Reguart N, Yang G, Li Y, Yao W, Vaddi K, Gazdar AF, Friedman SM, Jablons DM, Newton RC, Fridman JS, Minna JD, Scherle PA Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell, 2006-07-01;10(1):39-50. 2006-07-01 [PMID: 16843264] (Human)		Human
Show All 20 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Patricia Carulla Martí			06/22/2023	View Summary Sample Tested human dermal fibroblast,Supernatant from Human primary fibroblasts (HDFa) cultured in presence or absence of H2O2 Lot P1053100

Array DY377

• Neuregulin-1 beta 1/NRG1 beta 1 Antibodies
• Neuregulin-1 beta 1/NRG1 beta 1 Protein
• Neuregulin-1 beta 1/NRG1 beta 1 Proteins and Enzymes
• Neuregulin-1 beta 1/NRG1 beta 1 ELISA