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Human/Mouse BDNF DuoSet ELISA, 15 Plate

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

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Human/Mouse BDNF DuoSet ELISA, 15 Plate Summary

Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
BDNF

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY248.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human/Mouse BDNF DuoSet ELISA, 15 Plate

  • Abrineurin
  • ANON2
  • BDNF
  • brain-derived neurotrophic factor
  • BULN2
  • MGC34632
  • Neurotrophin

Background

BDNF (Brain-Derived Neurotrophic Factor) is a secreted protein that regulates many aspects of neuronal development and function in the nervous system. It is produced as proBDNF in response to neuronal activity or inflammatory stimulation and is then cleaved before associating into a homodimer. It is expressed throughout the nervous system as well as by fibroblasts, megakaryocytes/platelets, and smooth muscle cells. BDNF regulates neural stem cell survival and differentiation, axon/dendrite differentiation, synapse formation and maturation, and refinement of developing circuits. It is also a key regulator of synaptic plasticity and late-phase long-term potentiation. BDNF signals through the TrkB and NGF R/TNFRSF16 receptors. Secreted proBDNF can bind to NGF R/TNFRSF16 and induce long-term depression and cell apoptosis.

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Publications for BDNF (DY248)(77)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.


Filter By Application
All Applications
Filter By Species
Human
(57)
Mouse
(10)
Rat
(9)
All Species
Showing Publications 1 - 10 of 77. Show All 77 Publications.
Publications using DY248 Applications Species
Vega-Rosas, A;Flores-Ramos, M;Ramírez-Rodríguez, GB; Association Between the Enriched Environment Level and Serum Brain-Derived Neurotrophic Factor (BDNF) in Patients with Major Depressive Disorder Brain sciences 2024-11-13 [PMID: 39595900] (Human) Human
Delila, L;Nebie, O;Le, NTN;Timmerman, K;Lee, DY;Wu, YW;Chou, ML;Buée, L;Chou, SY;Blum, D;Devos, D;Burnouf, T; Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson's disease models Journal of biomedical science 2024-09-05 [PMID: 39237980] (Human) Human
Fonseca?Gomes, J;Costa-Coelho, T;Ferreira-Manso, M;Inteiro-Oliveira, S;Vaz, S;Alemãn-Serrano, N;Atalaia-Barbacena, H;Ribeiro?Rodrigues, L;Ramalho, R;Pinto, R;Miranda, H;Tanqueiro, S;Almeida-Borlido, C;Ramalho, M;Miranda?Lourenço, C;Belo, R;Ferreira, C;Neves, V;Rombo, D;Viais, R;Umemori, J;Martins, I;Jerónimo-Santos, A;Caetano, A;Manso, N;Mäkinen, P;Marttinen, M;Takalo, M;Bremang, M;Pike, I;Haapasalo, A;Loureiro, J;Pereira, M;Santos, N;Outeiro, T;Castanho, M;Fernandes, A;Hiltunen, M;Duarte, C;?astrén, E;Mendonça, A;Sebastião, A;Rodrigues, T;Diógenes, M; A Small TAT-TrkB Peptide Prevents BDNF Receptor Cleavage and Restores Synaptic Physiology in Alzheimer’s Disease Molecular Therapy 2024-08-28 [PMID: 39205389] (Human) Human
Duderstadt, Y;Schreiber, S;Burtscher, J;Schega, L;Müller, NG;Brigadski, T;Braun-Dullaeus, RC;Le beta mann, V;Müller, P; Controlled Hypoxia Acutely Prevents Physical Inactivity-Induced Peripheral BDNF Decline International journal of molecular sciences 2024-07-09 [PMID: 39062779] (Human) Human
Lengvenyte, A;Cognasse, F;Hamzeh-Cognasse, H;Sénèque, M;Strumila, R;Olié, E;Courtet, P; Baseline circulating biomarkers, their changes, and subsequent suicidal ideation and depression severity at 6 months: A prospective analysis in patients with mood disorders Psychoneuroendocrinology 2024-07-06 [PMID: 39003840] (Human) Human
Permoda-Pachuta, A;Malewska-Kasprzak, M;Skibi?ska, M;Rzepski, K;Dmitrzak-W?glarz, M; Changes in Adipokine, Resitin, and BDNF Concentrations in Treatment-Resistant Depression after Electroconvulsive Therapy Brain sciences 2023-09-22 [PMID: 37891727] (Human) Human
D?bkowska, M;Stukan, I;Kowalski, B;Donerowicz, W;Wasilewska, M;Szatanik, A;Sta?czyk-Dunaj, M;Michna, A; BDNF-loaded PDADMAC-heparin multilayers: a novel approach for neuroblastoma cell study Scientific reports 2023-10-20 [PMID: 37864014] (Human) Human
Ribeiro, R;Silva, EG;Moreira, FC;Gomes, GF;Cussat, GR;Silva, BSR;da Silva, MCM;de Barros Fernandes, H;de Sena Oliveira, C;de Oliveira Guarnieri, L;Lopes, V;Ferreira, CN;de Faria, AMC;Maioli, TU;Ribeiro, FM;de Miranda, AS;Moraes, GSP;de Oliveira, ACP;Vieira, LB; Chronic hyperpalatable diet induces impairment of hippocampal-dependent memories and alters glutamatergic and fractalkine axis signaling Scientific reports 2023-09-29 [PMID: 37773430] (Mouse) Mouse
Joo, MK;Shin, YJ;Kim, DH; Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice Scientific reports 2023-09-19 [PMID: 37726354] (Mouse) Mouse
Bang-Kittilsen, G;Egeland, J;Ueland, T;Andersen, E;Bigseth, TT;Holmen, TL;Mordal, J;Holst, R;Engh, JA; The relationship between the brain-derived neurotrophic factor and neurocognitive response to physical exercise in individuals with schizophrenia Psychoneuroendocrinology 2023-08-03 [PMID: 37562099] (Human) Human
Show All 77 Publications.

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Additional BDNF Products

Blogs on BDNF. Showing 1-10 of 11 blog posts - Show all blog posts.


  Read full blog post.

The use of a GFP antibody for research applications in transgenic C. elegans, GFP tagged yeast and porcine model
GFP, or green fluorescent protein, is a chemiluminescent protein derived from Aequorea jellyfish that was first discovered by Osamu Shimomura.  It was soon after established that the emission spectra of GFP was right around 509nm, or the ultraviol...  Read full blog post.

The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2
Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...  Read full blog post.

Niemann Pick-C1 and cholesterol dynamics
Niemann-Pick type C1 (NPC1) mediates low-density cholesterol transport from late endosomes and lysosomes to other areas of the cell via receptor mediation endocytosis.  Although cholesterol moves freely inside the cell, it cannot independently expo...  Read full blog post.

Synapsin I: Implicated in synaptic activity across a diverse range of studies
Synapsins are a family of neuronal proteins that are most renowned for their activity in modulating the pre-synaptic terminal.  Synapsin’s behavior is regulated by protein kinases and phosphatases, which alter the way that synapsin’s i...  Read full blog post.

TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its ...  Read full blog post.

TrkB and Nervous System Function
Neutrophins and their receptors play an important role in regulating the development of both the central and peripheral nervous systems. Neurotrophin ligand binding to each of their respective Trk cellular receptors is essential for the growth and sur...  Read full blog post.

TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...  Read full blog post.

BDNF Antibodies Aid Research on Alzheimer's Therapies
Brain-derived neurotrophic factor (BDNF) is known to be important for neuronal differentiation, survival, migration and plasticity in both the developing embryo and adult synapses. The BDNF antibody is also proving to be an important tool in Alzheimer...  Read full blog post.

BDNF Antibodies and Synaptic Research
Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophins. During development it regulates the survival and differentiation of neuronal cell populations in the central and peripheral nervous system, while in adult synapse...  Read full blog post.

Showing 1-10 of 11 blog posts - Show all blog posts.
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Bioinformatics

Gene Symbol BDNF