Human LDLR Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LDL R (Low Density Lipoprotein Receptor) is a widely expressed cell surface scavenger receptor. LDL R binds ApoB and ApoE, the apolipoproteins of low- and very low-density lipoproteins (LDL and VLDL), respectively. Hepatocyte LDL R is responsible for endocytosis and clearing of most plasma LDL cholesterol. At the low pH of the endocytic vesicle, it dissociates, allowing degradation of LDL and recycling of LDL R to the cell surface. Lack of LDL R expression or function causes familial hypercholesterolemia (FH). The protease PCSK9 can also cause increased plasma cholesterol by promoting LDL R degradation rather than recycling to the cell surface.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 3 of 3.

Publications using DLDLR0	Applications	Species
A Alabi, XD Xia, HM Gu, F Wang, SJ Deng, N Yang, A Adijiang, DN Douglas, NM Kneteman, Y Xue, L Chen, S Qin, G Wang, DW Zhang Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis Nature Communications, 2021-03-25;12(1):1889. 2021-03-25 [PMID: 33767172] (Human)		Human
XH Liang, H Sun, W Shen, S Wang, J Yao, MT Migawa, HH Bui, SS Damle, S Riney, MJ Graham, RM Crooke, ST Crooke Antisense oligonucleotides targeting translation inhibitory elements in 5' UTRs can selectively increase protein levels Nucleic Acids Res., 2017-09-19;45(16):9528-9546. 2017-09-19 [PMID: 28934489] (Human)		Human
SA Felt, GN Droby, VZ Grdzelishv Ruxolitinib and polycation combination treatment overcomes multiple mechanisms of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus J. Virol., 2017-07-27;0(0):. 2017-07-27 [PMID: 28566376] (Human)		Human

Array DLDLR0

• LDLR Antibodies
• LDLR Antibody Pair
• LDLR ELISA Kit
• LDLR Lysate
• LDLR Proteins
• LDLR ELISAs
• LDLR Proteins and Enzymes