Human DPPIV/CD26 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

DPPIV/CD26 is a serine exopeptidase that is expressed as a noncovalent homodimer on the surface of epithelial cells, endothelial cells, and activated lymphocytes. It regulates multiple aspects of immune and endocrine function by cleaving Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of a wide variety of chemokines (CCL4 and 5, CXCL6, 9, 10, 11, and 12), growth factors (GM-CSF, IL-3), and peptide hormones (Glucagon, Glucagon-like Peptides 1 and 2, GIP, GHRH, Procalcitonin, Neuropeptide Y, and Substance P). DPPIV interacts in cis with Adenosine Deaminase on T cells, in trans with Caveolin-1 on antigen presenting cells, and it serves as a cell entry coreceptor for HIV and coronavirus. It provides costimulatory proliferation and activation signals to both CD4+ and CD8+ T cells. A soluble form of DPPIV can be proteolytically shed from adipocytes, leading to insulin resistance in adipocytes and skeletal muscle.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 10.

Publications using DC260B	Applications	Species
Kandekar, S;Punatar, S;Khattry, N;Gokarn, A;Jindal, N;Mirgh, S;Chichra, A;Tembhare, P;Rane, P;Gawde, J;Mathew, L;Patil, A;Chiplunkar, S;Kode, J; Low levels of CD26 on certain cellular subtypes of donor harvest is associated with better clinical outcomes post allogeneic stem cell transplantation through regulation of NF-?B pathway and pro-inflammatory cytokines International immunopharmacology 2023-10-25 [PMID: 37890379] (Human)		Human
Vahsen, BF;Nalluru, S;Morgan, GR;Farrimond, L;Carroll, E;Xu, Y;Cramb, KML;Amein, B;Scaber, J;Katsikoudi, A;Candalija, A;Carcolé, M;Dafinca, R;Isaacs, AM;Wade-Martins, R;Gray, E;Turner, MR;Cowley, SA;Talbot, K; C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9 Nature communications 2023-09-22 [PMID: 37736756] (Human)		Human
KR Alkharsah, SA Aljaroodi, JU Rahman, AN Alnafie, R Al Dossary, RY Aljindan, AM Alnimr, J Hussen Low levels of soluble DPP4 among Saudis may have constituted a risk factor for MERS endemicity PLoS ONE, 2022-04-12;17(4):e0266603. 2022-04-12 [PMID: 35413090] (Human)		Human
T Saukkonen, SJ Mutt, J Jokelainen, AM Saukkonen, GS Raza, T Karhu, P Härkönen, J Eckel, KH Herzig, U Rajala, S Keinänen-K Adipokines and inflammatory markers in elderly subjects with high risk of type 2 diabetes and cardiovascular disease Sci Rep, 2018-08-24;8(1):12816. 2018-08-24 [PMID: 30143687] (Human)		Human
KS Inn, Y Kim, A Aigerim, U Park, ES Hwang, MS Choi, YS Kim, NH Cho Reduction of soluble dipeptidyl peptidase 4 levels in plasma of patients infected with Middle East respiratory syndrome coronavirus Virology, 2018-03-26;518(0):324-327. 2018-03-26 [PMID: 29587190] (Human)		Human
P Komolmit, K Charoensuk, K Thanapirom, S Suksawatam, P Thaimai, C Chirathawo, Y Poovorawan Correction of vitamin D deficiency facilitated suppression of IP-10 and DPP IV levels in patients with chronic hepatitis C: A randomised double-blinded, placebo-control trial PLoS ONE, 2017-04-04;12(4):e0174608. 2017-04-04 [PMID: 28376103] (Human)		Human
P Lourenço, S Silva, F Cunha, J Pereira, A Ribeiro, N Silva, JT Guimarães, JP Araújo, P Bettencour Dipeptidyl peptidase-IV in chronic heart failure with reduced ejection fraction Int. J. Cardiol, 2017-03-11;0(0):. 2017-03-11 [PMID: 28318663] (Human)		Human
Svensson H, Oden B, Eden S, Lonn M Adiponectin, chemerin, cytokines, and dipeptidyl peptidase 4 are released from human adipose tissue in a depot-dependent manner: an in vitro system including human serum albumin. BMC Endocr Disord, 2014-01-22;14(0):7. 2014-01-22 [PMID: 24447654] (Human)		Human
Yin M, Sillje HH, Meissner M, van Gilst WH, de Boer RA Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure. Cardiovasc Diabetol, 2011-09-28;10(0):85. 2011-09-28 [PMID: 21955567] (Human)		Human
Molica S, Digiesi G, Mirabelli R, Cutrona G, Antenucci A, Molica M, Giannarelli D, Sperduti I, Morabito F, Neri A, Baldini L, Ferrarini M Serum level of CD26 predicts time to first treatment in early B-chronic lymphocytic leukemia. Eur. J. Haematol., 2009-05-02;83(0):208-14. 2009-05-02 [PMID: 19459926] (Human)		Human

Array DC260B

• DPPIV/CD26 Antibodies
• DPPIV/CD26 ELISA Kits
• DPPIV/CD26 Kits
• DPPIV/CD26 Lysate
• DPPIV/CD26 Proteins
• DPPIV/CD26 Proteins and Enzymes
• DPPIV/CD26 ELISAs