Human Cathepsin D DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cathepsin D is a lysosomal aspartic protease of the pepsin family. Human Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 1 - 18), a propeptide (residues 19 - 64), and a mature chain (residues 65 - 412). The mature chain can be processed further to the light (residues 65 - 161) and heavy (residues 169 - 412) chains. It is expressed in most cells and over expressed in breast cancer cells. Cathepsin D is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in Cathepsin D have been shown to develop a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that Cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis.

We have publications tested in 1 confirmed species: Human.

Showing Publication 1 - 1 of 1.

Publication using DY1014-05	Applications	Species
F Chen, S Zhu, R Kang, D Tang, J Liu ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis Cell Reports, 2022-12-29;42(1):111911. 2022-12-29 [PMID: 36640329] (Human)		Human

Array DY1014-05

• Cathepsin D Antibodies
• Cathepsin D ELISA Kits
• Cathepsin D Lysate
• Cathepsin D Protein
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• Cathepsin D ELISA