Histone H3.1 Antibody

In eukaryotes, DNA is wrapped around histone octamers to form the basic unit of chromatin structure. The octamer is composed of Histones H2A, H2B, H3 and H4, and it associates with approximately 200 base pairs of DNA to form the nucleosome. The association of DNA with histones results in dense packing of chromatin, which restricts proteins involved in gene transcription from binding to DNA. Histone H3, the core protein of the nucleosome, becomes phosphorylated at the end of prophase. The two major sites of phosphorylation are the mitosis-specific site Ser 10 and Ser 28, both of which are extensively phosphorylated in DNA-bound forms of Histone H3 and in nucleosomal Histone H3. The nucleosome structure of Histone H3 promotes N-terminal phosphorylation in vitro. Phosphorylation of Histone H3 at Ser 10 is an essenti

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IP, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP2-75524	Applications	Species
Xu H, Akinyemi IA, Haley J et al. ATM, KAP1 and the Epstein-Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication Nucleic acids research 2023-10-19 [PMID: 37852757] (IP, Human)	IP	Human
Zhu J, Chen K, Sun YH et al. LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei Nature communications 2023-02-21 [PMID: 36810573] (WB, Mouse)	WB	Mouse
Yang W, Zhou J, Zhang Z et al. Downregulation of lncRNA APCDD1L-AS1 due to DNA hypermethylation and loss of VHL protein expression promotes the progression of clear cell renal cell carcinoma International Journal of Biological Sciences 2022-03-21 [PMID: 35414787] (WB, Human)	WB	Human

Array NBP2-75524

• Histone H3.1 Antibodies
• Histone H3.1 Lysate