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GRK2 [p Ser670] Antibody (HL1035)

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Biological Strategies: Western Blot: GRK2 [p Ser670] Antibody (HL1035) [NBP3-13688] - Untreated (-) and treated (+) Jurkat whole cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted ...read more
Immunohistochemistry-Paraffin: GRK2 [p Ser670] Antibody (HL1035) [NBP3-13688] - GRK2 (phospho Ser670) antibody [HL1035] detects GRK2 (phospho Ser670) protein at cell membrane and cytoplasm by immunohistochemical ...read more
Biological Strategies: Western Blot: GRK2 [p Ser670] Antibody (HL1035) [NBP3-13688] - Untreated (-) and treated (+) Jurkat whole cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted ...read more
Western Blot: GRK2 [p Ser670] Antibody (HL1035) [NBP3-13688] - Non-transfected (-) and transfected (+) 293T whole cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with GRK2 (phospho ...read more
Western Blot: GRK2 [p Ser670] Antibody (HL1035) [NBP3-13688] - Various whole cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with GRK2 (phospho Ser670) antibody [HL1035] (NBP3-13688) ...read more
Western Blot: GRK2 [p Ser670] Antibody (HL1035) [NBP3-13688] - Various tissue extracts (50 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with GRK2 antibody [HL1035] (NBP3-13688) diluted at 1:500. The ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC
Clone
HL1035
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
   

Biological Strategies

     

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GRK2 [p Ser670] Antibody (HL1035) Summary

Description
Centrifuge briefly prior to opening.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
Carrier-protein conjugated synthetic peptide surrounding phospho Ser670 of human GRK2. The exact sequence is proprietary.
Modification
p Ser670
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
GRK2
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A purified

Alternate Names for GRK2 [p Ser670] Antibody (HL1035)

  • ADRBK1
  • adrenergic, beta, receptor kinase 1
  • BARK
  • BARK1
  • BARK1beta-ARK-1
  • Beta-ARK1
  • Beta-ARK-1
  • EC 2.7.11
  • EC 2.7.11.15
  • FLJ16718
  • G-protein coupled receptor kinase 2
  • GRK2
  • GRK2beta-adrenergic receptor kinase 1

Background

Adrenergic Receptor beta Kinase 1 (ADRBK1), also known as GRK2, is a member of the G-protein receptor kinase family. A ubiquitous cytosolic enzyme, GRK-2 specifically phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed under high agonist concentrations. Defects in GRK2 coupling with G-protein receptors may lead to heart failure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Research Areas for GRK2 Antibody (NBP3-13688)

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The beta-arrestin family regulate receptor binding of G-proteins, a group of seven transmembrane receptor proteins which includes the adrenergic, dopamine and serotonin receptors. Recently, arrestin antibodies were used in a study into Serotonin Syndr...  Read full blog post.

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Bioinformatics

Gene Symbol GRK2