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GNAQ Antibody (GNAQ/2434) [Janelia Fluor® 525]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, ICC/IF
Clone
GNAQ/2434
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 525

Order Details

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GNAQ Antibody (GNAQ/2434) [Janelia Fluor® 525] Summary

Immunogen
Recombinant full-length human GNAQ protein (Uniprot: P50148)
Localization
Cytoplasmic and Cell Surface
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
GNAQ
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for GNAQ Antibody (GNAQ/2434) [Janelia Fluor® 525]

  • GAQG-ALPHA-q
  • guanine nucleotide binding protein (G protein), q polypeptide
  • Guanine nucleotide-binding protein alpha-q
  • guanine nucleotide-binding protein G(q) subunit alpha

Background

GNAQ, also known as Guanine nucleotide-binding protein G(q) subunit alpha, is a 359 amino acid that is 42 kDa, with subcellular nucleus location, expressed in ovary, prostate, testis and colon tissue; necessary modulator or transducer in various transmembrane signaling systems; controls B-cell selection and survival, needed to prevent B-cell-dependent autoimmunity; and also regulates chemotaxis of BM-derived neutrophils and dendritic cells. Studies on this protein have shown a relationship with the following diseases and disorders: bleeding diathesis due to gnaq deficiency, cellular blue nevus, pertussis, melanoma, acanthocytosis, fainting, polycystic ovary syndrome, trypanosomiasis, gitelman syndrome chorea, thyroid nodule, huntington's disease, thyroiditis, chagas disease, alzheimer's disease, melanoma metastasis, vasculitis, neuronitis, erythroleukemia, and heart failure. GNAQ has also shown an interaction with AGTR1, CXCR5, CRHR1, GALR2, HTR2C, and over 100 other interacting proteins in many different pathways including calcium signaling pathway, vascular smooth muscle contraction, gap junction, long-term potentiation, glutamatergic synapse, GPCR downstream signaling, hemostasis, gastrin-CREB signalling pathway via PKC and MAPK, signaling by GPCR, signal amplification.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional GNAQ Products

Array NBP3-08585JF525

Research Areas for GNAQ Antibody (NBP3-08585JF525)

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Bioinformatics

Gene Symbol GNAQ