GABA-AR alpha 3 Antibody

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Poltl et al., 2003).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-61096	Applications	Species
Li S, Jiang X, Wu Q et al. Electroacupuncture Suppresses CCI-Induced Neuropathic Pain through GABAA Receptors Evidence-based complementary and alternative medicine : eCAM 2022-10-07 [PMID: 36248405] (WB, Rat)	WB	Rat
Yamasaki T, Hoyos-Ramirez E, Martenson JS et al. GARLH Family Proteins Stabilize GABAA Receptors at Synapses.. Neuron. 2017-03-08 [PMID: 28279354]
Schwirtlich M, Emri Z, Antal K et al. GABAA and GABAB receptors of distinct properties affect oppositely the proliferation of mouse embryonic stem cells through synergistic elevation of intracellular Ca2+. FASEB J. [PMID: 19959723] (ICC/IF, Mouse)	ICC/IF	Mouse

Array NB100-61096

• GABA-AR alpha 3 Antibodies
• GABA-AR alpha 3 Lysate
• GABA-AR alpha 3 Proteins