FoxP2 Antibody

This gene encodes an evolutionarily conserved transcription factor expressed in fetal and adult brain. This transcription factor is a member of the forkhead/winged-helix (FOX) family of transcription factors, and contains a FOX DNA-binding domain and a large polyglutamine tract. Members of the FOX family of transcription factors are regulators of embryogenesis. The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis. Although a point mutation in this gene has been associated with the KE pedigree segregating developmental verbal dyspraxia, no association between mutations in this gene and another speech disorder, autism, has been found. Four alternative transcripts encoding three different isoforms have been identified.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 3 applications: Chemotaxis, ICC/IF, IHC-Fr.

Showing Publications 1 - 8 of 8.

Publications using NB100-55411	Applications	Species
Duque A, Gazula VR, Kaczmarek LK. Expression of Kv1.3 potassium channels regulates density of cortical interneurons. Dev Neurobiol 2013-07-02 [PMID: 23821603] (ICC/IF, IHC-Fr, Mouse)	ICC/IF, IHC-Fr	Mouse
Lai CS, Fisher SE, Hurst JA et al. A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 2001-10-04 [PMID: 11586359]
Clayton K, Williamson R, Watanabe Y et al. Motor corollary discharge activates layer six circuits in the auditory cortex bioRxiv 2020-05-31
Ramirez M, Badayeva Y, Yeung J et al. Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions eLife 2022-08-09 [PMID: 35942939] (IHC-Fr, Mouse) Details: C57BL/6 ?J mice, used at 1:2000 dilution	IHC-Fr	Mouse
Clayton KK, Williamson RS, Hancock KE et al. Auditory Corticothalamic Neurons Are Recruited by Motor Preparatory Inputs Curr Biol 2020-10-28 [PMID: 33157020] (Mouse)		Mouse
Stam FJ, Hendricks TJ, Zhang J et al. Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program. Development 2011-11-24 [PMID: 22115757] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Prasad T, Wang X, Gray PA et al. A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-{gamma} gene cluster. Development 2008-12-01 [PMID: 19029045] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Zhou B, Zhong Q, Minoo P et al. Foxp2 Inhibits Nkx2.1-Mediated Transcription of SP-C via Interactions with the Nkx2.1 Homeodomain. Am J Respir Cell Mol Biol 2008-06-01 [PMID: 18239190] (Chemotaxis, Rat)	Chemotaxis	Rat

Array NB100-55411

• FoxP2 Antibodies
• FoxP2 Lysate
• FoxP2 Proteins