Factor IX Antibody (emicizumab) - Humanized Summary
Description |
Expressed from CHO. The heavy chain type is huIgG4SP, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.
Also known as 'emicizumab'.
Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles. |
Additional Information |
Recombinant Monoclonal Antibody |
Immunogen |
F9 / Factor IX |
Isotype |
IgG4 |
Clonality |
Monoclonal |
Host |
Human |
Gene |
F9 |
Purity |
Protein A purified |
Endotoxin Note |
< 0.001EU/ug,determined by LAL method. |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- ELISA
- Flow Cytometry
- Functional
|
Packaging, Storage & Formulations
Storage |
Store at 4C. |
Buffer |
Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2) |
Preservative |
No Preservative |
Concentration |
LYOPH |
Purity |
Protein A purified |
Reconstitution Instructions |
Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex. |
Alternate Names for Factor IX Antibody (emicizumab) - Humanized
Background
Factor IX encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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