Factor IX Products

Description

Factor IX encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.

Bioinformatics

Entrez	2158 Human
Uniprot	NM_000133 Human NP_000124 Human NP_000124.1 Human P00740 Human
Product By Gene ID	2158
Alternate Names	Christmas factor coagulation factor IX EC 3.4.21 EC 3.4.21.22 factor 9 FIX HEMB MGC129641 MGC129642 plasma thromboplastic component Plasma thromboplastin component PTC