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DPPII/QPP/DPP7 Antibody (398011) [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications B/N
Clone
398011
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price
Carrier Free
MAB3438-SP
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DPPII/QPP/DPP7 Antibody (398011) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human DPPII/QPP/DPP7
Gly22-Leu492
Accession # ABM85563
Specificity
Detects human DPPII/QPP/DPP7 in direct ELISAs.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
DPP7
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
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Applications/Dilutions

Dilutions
  • Neutralization 0.12 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DPPII/QPP/DPP7 Antibody (398011) [Unconjugated]

  • carboxytripeptidase
  • Dipeptidyl aminopeptidase II
  • dipeptidyl arylamidase II
  • dipeptidyl peptidase 2
  • Dipeptidyl peptidase 7
  • Dipeptidyl peptidase II
  • dipeptidylpeptidase 7
  • dipeptidyl-peptidase 7
  • dipeptidyl-peptidase II
  • DPP II
  • DPP2
  • DPP7
  • DPPII
  • EC 3.4.14.2
  • QPP
  • Quiescent cell proline dipeptidase

Background

Dipeptidyl-peptidase II (DPPII) is identical to quiescent cell proline dipeptidase (QPP) and dipeptidylpeptidase 7 (DPP7) (1, 2). It shares some substrate and cleavage specificity with DPPIV/CD26, DPP8, DPP9 and seprase/FAP (fibroblast activation protein), members of the S09 family of serine proteases. As prolyl proteases that cleave proteins and peptides after proline residues, these enzymes have high potential for drug discovery (3, 4). However, DPP7 is not a member of the S09 family, but a member of the S28 family that also includes lysosomal Pro-X carboxypeptidase/prolylcarboxypeptidase/PRCP and thymus-specific serine peptidase/PRSS16 (2). The human DPP7 precursor consists of a signal peptide (aa 1‑21) and a mature chain (aa 22‑492). The purified rhDPP7 is active against Lys‑Pro‑AMC and Lys‑Ala‑AMC. Its activity against Lys‑Pro‑AMC is approximately 10‑fold of that against Lys‑Ala‑AMC under otherwise identical conditions.

  1. Underwood, R. et al. (1999) J. Biol. Chem. 274:34053.
  2. Maes, M.B. et al. (2005) Biochem. J. 386:315.
  3. Rosenblum, J.S. and J.W. Kozarich (2003) Curr. Opin. Chem. Biol. 7:496.
  4. Lankas, G.R. et al. (2005) Diabetes 54:2988.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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DPPII/QPP/DPP7
Antibody (398011) [Un ...
MAB3438
DPPII/QPP/DPP7 Antibody (398011) [Unconjugated]
Species: Hu
Applications: B/N

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Bioinformatics

Gene Symbol DPP7
Uniprot