Calcium-sensing R/CaSR Antibody (611825) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Calcium-sensing receptor (CasR) is a plasma membrane G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (1). CasR is expressed in the parathyroid hormone-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule (2). Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism (3). The full length of CasR has a large extracellular N-terminal domain, a central region of 7 transmembrane domains, and a long intracellular C‑terminal domain. The amino acid 20-601 contains the extracellular domain with multiple glycosylation sites (4). Human CasR shares 96.1% and 96.5% aa sequence identity with mouse and rat CasR, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB9608

• Calcium-sensing R/CaSR Antibodies
• Calcium-sensing R/CaSR ELISA Kits
• Calcium-sensing R/CaSR Lysate
• Calcium-sensing R/CaSR Proteins
• Calcium-sensing R/CaSR Proteins and Enzyme