BCAR3 Antibody

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publication 1 - 1 of 1.

Publication using NB100-87003	Applications	Species
Sun G, Cheng SY, Chen M et al. Protein tyrosine phosphatase alpha phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions. Mol Cell Biol 2012-09-01 [PMID: 22801373]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Human	07/18/2017	View Summary Application Western Blot Sample Tested GST-pull down assay,MDA-MB-231 total lysate Species Human Lot A1
	5 reviewed by: Verified Customer	WB	Human	02/09/2010	View Summary Application Western Blot Sample Tested human pancreatic cancer cell lines and human pancreatic primary tumors, Sample Amount: 30 to 40 ug Species Human

Array NB100-87003

• BCAR3 Antibodies
• BCAR3 Lysate
• BCAR3 Protein