BAK BH3 Synthetic Peptide GQVGRQLAIIGDDINR Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bcl-2-antagonist/killer (BAK), also known as BAK1 and Bcl-2-like Protein 7, is a proaptoptotic member of the Bcl-2 protein family with a predicted molecular weight of approximately 23 kDa. It contains four Bcl-2 homology domains, BH1-BH4, and a C-terminal transmembrane domain. Human BAK shares 77% amino acid sequence identity with the mouse and rat orthologs. BAK primarily localizes to the outer mitochondrial membrane where it is redundantly required, along with Bax, for the release of Cytochrome c during apoptosis. Cytochrome c release may occur through pores formed by homo-oligomerization of BAK within the mitochondrial outer membrane. BAK can be directly activated by BID, BIM, and PUMA, which are also members of the Bcl-2 family. Additionally, p53 can directly activate BAK in response to cell stress. BAK may also be involved in crosstalk between the apoptosis and autophagy pathways.

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: In Vivo.

Showing Publication 1 - 1 of 1.

Publication using 881-BA	Applications	Species
Childs EW, Tharakan B, Hunter FA, Tinsley JH, Cao X Apoptotic signaling induces hyperpermeability following hemorrhagic shock. Am. J. Physiol. Heart Circ. Physiol., 2007-02-16;292(6):H3179-89. 2007-02-16 [PMID: 17307990] (In Vivo, Rat)	In Vivo	Rat

Array 881-BA

• BAK Antibodies
• BAK ELISA Kits
• BAK Lysate
• BAK Protein
• BAK Proteins and Enzymes