Apolipoprotein E/ApoE Antibody (WUE-4) [Biotin] Summary
Immunogen |
Purified human ApoE [UniProt# P02649] |
Epitope |
Residues 140-160 of purified human ApoE (LDLR receptor binding site). |
Localization |
Secreted |
Specificity |
This antibody detects ApoE2, ApoE3 and ApoE4 (PMID 2466929). |
Isotype |
IgG1 Kappa |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
APOE |
Purity |
Protein G purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- CyTOF-ready
- ELISA
- Flow (Intracellular)
- Flow Cytometry
- Immunocytochemistry/ Immunofluorescence
- Immunohistochemistry
- Immunohistochemistry-Paraffin
- Immunoprecipitation
- Western Blot
|
Application Notes |
Optimal dilution of this antibody should be experimentally determined. |
Readout System |
|
Reactivity Notes
Reacts with human better than mouse. It does not appear to react with rat brain tissue.
Packaging, Storage & Formulations
Storage |
Store at 4C in the dark. |
Buffer |
PBS |
Preservative |
0.05% Sodium Azide |
Purity |
Protein G purified |
Alternate Names for Apolipoprotein E/ApoE Antibody (WUE-4) [Biotin]
Background
Lipoproteins are responsible for carrying cholesterol and other fats through the bloodstream as little packages and are essential for the normal breakdown of these molecules. In particular, apolipoprotein E is a major component of specific lipoproteins called very low-density lipoproteins (VLDL). A major function of VLDLs is to remove excess cholesterol from the blood and carry it to the liver for processing. Maintaining normal levels of cholesterol is essential for the prevention of cardiovascular diseases, including heart attacks and strokes.
Apolipoprotein E is a type of lipoprotein. Apolipoprotein E is associated with several cardiovascular disorders. There are three isoforms (slightly different forms) of the ApoE lipoprotein. These three isoforms are known as ApoE2, E3 and E4. ApoE2 seems to be one of several genetic factors that plays a part in increased risk of heart attacks and strokes and ApoE4 is a risk factor for coronary artery disease. As well, ApoE4 has been been suggested to play a role in type 2 Alzheimer disease.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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