alpha-Sarcoglycan Antibody (769109)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alpha-sarcoglycan is one of six known sarcoglycans, which are type I ( alpha - and epsilon -) or type II ( beta -, gamma -, δ- or zeta -) transmembrane glycoproteins. Sarcoglycans alpha and gamma are expressed exclusively in the sarcoplasmic reticulum in skeletal and cardiac muscle, while others are more widely expressed. Sarcoglycans form heterotetrameric, pentameric and hexameric membrane glycoprotein complexes (SGC). SGC interacts laterally with the dystroglycan complex, and both complexes are components of the dystrophin-associated glycoprotein complex (DGC), which forms a link between the cytoskeleton and the extracellular matrix. Mutations in sarcoglycans are associated with recessive autosomally inherited limb-girdle muscular dystrophy. Human alpha -sarcoglycan shares 90% amino acid sequence identity with mouse and rat alpha -sarcoglycan within the extracellular domain.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB7445

• alpha-Sarcoglycan Antibodies
• alpha-Sarcoglycan Lysate
• alpha-Sarcoglycan Proteins