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ADAM19 Antibody [Biotin]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Sheep
Conjugate
Biotin
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Unconjugated
AF5050
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
AF5050
Carrier Free
AF5050
Carrier Free
AF5050-SP
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ADAM19 Antibody [Biotin] Summary

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human ADAM19
Arg26-Gln501
Accession # Q9H013
Marker
Dendritic Cell Marker
Specificity
Detects human ADAM19 in Western blots. In Western blots, approximately 25% cross-reactivity with recombinant mouse ADAM19 is observed and less than 5% cross-reactivity with recombinant human (rh) ADAM8, rhADAM12, and rhADAM33 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
ADAM19
Purity Statement
Antigen Affinity-purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
Readout System

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ADAM19 Antibody [Biotin]

  • a disintegrin and metalloproteinase domain 19 (meltrin beta)
  • ADAM 19
  • ADAM metallopeptidase domain 19
  • ADAM19
  • disintegrin and metalloproteinase domain-containing protein 19
  • EC 3.4.24
  • EC 3.4.24.-
  • MADDAM
  • Meltrin beta
  • meltrin-beta
  • Metalloprotease and disintegrin dendritic antigen marker
  • MLTNBmeltrin beta

Background

ADAM19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrin-beta ) is a 95‑100 kDa member of the M12B peptidase family of enzymes. It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells. The human ADAM19 proenzyme is a 931 amino acid (aa) type I transmembrane protein. It contains a 178 aa cleavable proregion (aa 26‑203) and a 497 aa extracellular domain (ECD) (aa 204‑702). The ECD contains a metalloprotease domain (aa 211‑409), a disintegrin region (aa 417‑503) and a Cys-rich domain (aa 504‑650). The ECD circulates in plasma bound to 700 kDa alpha 2-Macroglobulin. One splice variant shows an alternate start site at Met71, while two isoforms show variations after Lys902. Over aa 205‑702, human ADAM19 is 87% aa identical to mouse ADAM19.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ADAM19
Uniprot