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Optic Vesicle Morphogenesis Pathway Bioinformatics

Disease and disorder research has been conducted in relation to the Optic Vesicle Morphogenesis Pathway and Protrusion, Microphthalmos, Congenital Ocular Coloboma (disorder), Eye Abnormalities. The study of the Optic Vesicle Morphogenesis Pathway has been mentioned in research publications which can be found using our bioinformatics tool below. The Optic Vesicle Morphogenesis Pathway has been researched in relation to Eye Development, Eye Morphogenesis, Cell Migration, Neural Plate Morphogenesis. The Optic Vesicle Morphogenesis Pathway complements our catalog of research reagents including antibodies and ELISA kits against BMP4, NR2F1, PAX2, MITF, NR2F2.

Top Research Reagents

We have 1899 products for the study of the Optic Vesicle Morphogenesis Pathway that can be applied to Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

LMX1b Antibody

NBP1-36970

Immunohistochemistry-Paraffin: LMX1b Antibody [NBP1-36970] - (2.5ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Goat Polyclonal
Species Human, Mouse, Rat
Applications IHC, IHC-P, PEP-ELISA

1 Publication

VAX1 Antibody (2F4)

H00011023-M03

Western Blot: VAX1 Antibody (2F4) [H00011023-M03] - Analysis of VAX1 expression in Raw 264.7 (Cat # L024V1).

Western Blot: VAX1 Antibody (2F4) [H00011023-M03] - Analysis of VAX1 expression in PC-12 (Cat # L012V1).

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, S-ELISA

1 Review

CHX10 Antibody

NBP1-84476

Western Blot: CHX10 Antibody [NBP1-84476] - Analysis in control (vector only transfected HEK293T lysate) and vSX2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Immunohistochemistry-Paraffin: CHX10 Antibody [NBP1-84476] - Staining of human skeletal muscle shows no nuclear positivity in myocytes as expected.

Rabbit Polyclonal
Species Human, Rat
Applications WB, IHC, IHC-P

8 Publications

Fibronectin Antibody - BSA Free

NBP1-91258

Western Blot: Fibronectin Antibody - BSA Free [NBP1-91258] - VSOP observed in perivascular-restricted spinal cord lesions with intact BBB. Immunostaining for laminin (brown) shows vascular endothelium and glia limitans of a perivascular lesion, along with infiltrating cells and VSOP (blue). Image collected and cropped by CiteAb from the following publication (https://asn.sagepub.com/lookup/doi/10.1042/AN20120081), licensed under a CC-BY license.

Immunocytochemistry/Immunofluorescence: Fibronectin Antibody - BSA Free [NBP1-91258] - NIH3T3 cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.05% Triton X-100 in PBS for 5 minutes. The cells were incubated with anti- NBP1-91258 at 1 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:1000 dilution for 60 minutes. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 100X objective and digitally deconvolved.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

11 Reviews

56 Publications

Otx2 Antibody [Unconjugated]

AF1979

Western blot shows lysates of IMR-32 human neuroblastoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human Otx2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1979) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Otx2 was detected in immersion fixed NTera-2 human testicular embryonic carcinoma cell line using Goat Anti-Human Otx2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1979) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&#8482; 557-conjugated Anti-Goat IgG Secondary Antibody (yellow, upper panel; Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, Simple Western, IHC

2 Reviews

167 Publications

FoxD3 Antibody

AF2819

Western blot shows lysates of HEK293 human embryonic kidney cell line either mock transfected or transfected with human FoxD3. PVDF Membrane was probed with 1 µg/mL of Sheep Anti-Human FoxD3 aa 1-140 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2819) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <a class=

FoxD3 was detected in immersion fixed BG01V human embryonic stem cells using Sheep Anti-Human FoxD3 aa 1-140 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2819) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&#8482; 557-conjugated Anti-Sheep IgG Secondary Antibody (red, upper panel; Catalog # <a class=

Sheep Polyclonal
Species Human
Applications WB, ICC

Pax2 Antibody [Unconjugated]

AF3364

Western blot shows lysates of mouse fetal kidney. PVDF Membrane was probed with 1&nbsp;µg/mL of Goat Anti-Human Pax2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3364) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (<a class=

Pax2 was detected in immersion fixed BG01V human embryonic stem cells differentiated into the early otic lineage using Goat Anti-Human Pax2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3364) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&#8482; 557-conjugated Anti-Goat IgG Secondary Antibody (red; <a class=

Goat Polyclonal
Species Human
Applications WB, IHC, ICC

24 Publications

MITF Antibody

AF5769

MITF was detected in paraffin-embedded sections of human skin using Goat Anti-Human MITF Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5769) at 10 &micro;g/mL overnight at 4 &deg;C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # <a class=

Western blot shows lysates of Bowes human melanoma cell line and HeLa human cervical epithelial carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human MITF Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5769) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, IHC

9 Publications

Pax6 Antibody [Unconjugated]

AF8150

Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line and rat cortical stem cells. PVDF membrane was probed with 0.5 µg/mL of Sheep Anti-Human Pax6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF8150) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <a class=

Immersion fixed SA01 human embryonic stem cells were differentiated for 6&nbsp;days with Recombinant Human Noggin (Catalog&nbsp;# <A class=NoLineLink href=

Sheep Polyclonal
Species Human
Applications WB, Simple Western, ICC

16 Publications

SOX2 Antibody [Unconjugated]

AF2018

Western blot shows lysates of D3 mouse embryonic stem cell line, NTera-2 human testicular embryonic carcinoma cell line, F9 mouse teratocarcinoma stem cells, and rat cortical stem cells. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat SOX2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2018) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (<a class=

BG01V human embryonic stem cells were fixed using formaldehyde, resuspended in lysis buffer, and sonicated to shear chromatin. SOX2/DNA complexes were immunoprecipitated using 5 µg Goat Anti-Human/Mouse/Rat SOX2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2018) or control antibody (<a class=

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, IHC

6 Reviews

354 Publications

COUP-TF II/NR2F2 Antibody (H7147) [Unconjugated]

PP-H7147-00

Reduction of COUP-TFII or nucleolin decreases RAR beta 2 transcription in MCF-7 cells.MCF-7 (A) and T47D (B) cells were transfected with control siRNA or an siRNA targeting nucleolin for 48 h. T47D cells were treated with EtOH or 1 µM atRA for 24 h. Q-PCR for nucleolin (NCL) and RARB2. Values are the average of triplicates. C, Western blot showing COUP-TFII and RAR beta 2 expression after transfection with siCOUP-TFII. Values are relative to beta -actin. MCF-7 were transfected with siControl or siCOUP-TFII for 48 h and treated with 1 µM atRA for 6 h. Q-PCR was also performed for RRIG1. P<0.001 * versus control or ** versus atRA. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0038278), licensed under a CC-BY license. Not internally tested by R&D Systems.

Loss of miR-101 promotes cancer metastasis through de-repression of COUP-TFII expression.(a) LNCaP and PC3 cells were individually treated with 50 nM of miR-101 and miR-27a mimic for 48 h and then invasion assays were performed for an additional 16 h (n=3). *P<0.05 (two-sided Student's t-test) compared with the control group. (b) Representative western blot showed the levels of COUP-TFII, E-cadherin, vimentin and beta -actin in PC3 cells stably knocked down by COUP-TFII. (c) LNCaP and PC3 cells stably knocked-down of COUP-TFII were used to perform cell invasion assay. Invaded cells were stained and counted (lower panel) (n=3). Representative western blot showed the knockdown efficiency of COUP-TFII (upper panel). *: P<0.05 (two-sided Student's t-test) compared with control group. (d) PC3 cells carrying an inducible miR-101 in the absence and presence of doxycycline, and re-expression of COUP-TFII were used to perform invasion assays (n=3). Representative western blot showed the levels of COUP-TFII and beta -actin (left). Invaded cells were counted and results are shown in the right panel. *: P<0.05 (two-sided Student's t-test) (e) 22RV-1 cells were treated with miR-101 inhibitor (antisense RNA) in conjunction with knockdown of COUP-TFII and used for invasion assays (n=3). Representative western blot show the levels of COUP-TFII and beta -actin (left). Invaded cells were counted and result is shown in the right panel. *: P<0.05 (two-sided Student's t-test). (f) LNCaP cells containing a construct with inducible expression of COUP-TFII shRNA and constructs expressing with anti-miR-101 and anti-mir-27a were orthotopically injected into NOD-SCID mouse prostate. In addition these cells also contain a luciferase reporter to detect cancer cells. After the tumour size was bigger than 50 mm3, drinking water with or without doxycycline (1 mg ml−1) was given to the mice for 6 weeks to induce the COUP-TFII shRNA to repress COUP-TFII expression. Representative bioluminescence results show the status of tumour growth in different groups. (g) Quantification result of luminance from IVIS (control: n=5; anti-miR-101/27a(−): n=6; anti-miR-101/27a(+): n=7. *: P<0.05 (two-sided Student's t-test). (h) Immunohistochemical stain showed the metastatic tumour cells located in the mouse lymph node are positive for AR. Scale bar: 100 μM (low power); and 200 μM (high power). SCID, severe combined immunodeficient. Image collected and cropped by CiteAb from the following publication (https://www.nature.com/articles/ncomms11418), licensed under a CC-BY license. Not internally tested by R&D Systems.

Mouse Monoclonal
Species Human
Applications WB, IHC, IP

3 Reviews

44 Publications

COUP-TF I/NR2F1 Antibody (H8132) [Unconjugated]

PP-H8132-00

Mouse Monoclonal
Species Human
Applications WB, IHC, IP

13 Publications

GDF-6/BMP-13

855-G6/CF

Species Mouse
Applications BA

3 Publications

BMP-2 [Unconjugated]

355-BM

Recombinant human/mouse/rat BMP-2 (<a class=NoLineLink href=

Species Human, Mouse, Rat
Applications BA

187 Publications

BMP-7 [Unconjugated]

354-BP

Recombinant human BMP-7 (<a class=NoLineLink href=

Adult stem cell-derived liver organoids were cultured using Cultrex UltiMatrix RGF Basement Membrane Extract (BME001-05) and liver organoid initiation medium, which includes Recombinant Human BMP-7 (Catalog # 354-BP), Recombinant Human HGF (<a class=

Species Human
Applications BA

94 Publications

BMP-4 [Unconjugated]

314-BP

Recombinant Human BMP‑4 (Catalog # 314-BP) induces BMP responsive SEAP reporter activity in HEK293 human embryonic kidney cells. The ED<sub>50</sub> for this effect is 0.70-7.00 ng/mL.

1 ug/lane of Recombinant Human BMP-4 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing major bands at 22-25 kDa and 37-41 kDa, respectively. Multiple bands in gel are due to variable glycosylation.<p style=

Species Human
Applications BA, BA

504 Publications

LHX2 Antibody (CL6137)

NBP2-61435

Western Blot: LHX2 Antibody (CL6137) [NBP2-61435] - Analysis in human cerebral cortex tissue.

Immunohistochemistry-Paraffin: LHX2 Antibody (CL6137) [NBP2-61435] - Staining of mouse embryo E14 shows strong nuclear immunoreactivity in the developing cortex and sensory organs.

Mouse Monoclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

Smad5 [p Ser463, p Ser465] Antibody (SY09-03)

NBP2-67394

Western Blot: Smad5 [p Ser463, p Ser465] Antibody (SY09-03) [NBP2-67394] - Analysis of Phospho-Smad5(S463/465) on different lysates using anti-Phospho-Smad5(S463/465) antibody at 1/1,000 dilution. Positive control: Lane 1: Mouse brain Lane 2: Rat brain

Immunocytochemistry/Immunofluorescence: Smad5 [p Ser463, p Ser465] Antibody (SY09-03) [NBP2-67394] - Staining Phospho-Smad5(S463/465) in SKOV-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

1 Publication

Related Genes

The Optic Vesicle Morphogenesis Pathway has been researched against:

Related Pathways

The Optic Vesicle Morphogenesis Pathway has been linked to:

Related Diseases

The Optic Vesicle Morphogenesis Pathway has been studied in relation to diseases such as:

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