MHC Class I Products

Description

The antigenic agglomerate major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8-positive T cells. It is now recognized that the products of the MHC genes are antigen-presenting molecules (APM) designed for the presentation of antigen fragments (peptides) to the T-cell receptor, thus participating in the immune response (1). Recently shown is a mechanism of antigen acquisition for cross-presentation that couples the antigen presentation system of two adjacent cells and is lost in most tumours: gap-junction-mediated intercellular peptide coupling for presentation by bystander MHC class I molecules and transfer to professional antigen presenting cells for cross-priming (2). The mammalian vomeronasal organ detects social information about gender, status, and individuality. It has been shown that small peptides that serve as ligands for major histocompatibility complex (MHC) class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal Gao- and V2R receptor-expressing zone of the vomeronasal epithelium (3).

Bioinformatics

Entrez	14972 Mouse 3133 Human
Uniprot	AAH02578 Human AAH02578.1 Human P30443 Human
Product By Gene ID	3133
Alternate Names	DKFZp686P19218 EA1.2 EA2.1 HLA class I histocompatibility antigen, alpha chain E HLA class I histocompatibility antigen, E alpha chain HLA-6.2 HLAE lymphocyte antigen major histocompatibility complex, class I, E MHC class I antigen E MHC HLA-E alpha-1 MHC HLA-E alpha-2.1 MHC QA1

Research Areas for MHC Class I

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology
Major Histocompatibility Complexes

Related MHC Class I Blog Posts

Check out the latest blog posts on MHC Class I.

MHC Class I and the Herpes Simplex Virus MHC molecules (also known as major histocompatibility complex molecules) assist in the presentation of antigens to T cells in order to eradicate foreign pathogens.  These molecules are highly polymorphic, meaning that they exist in multiple varian...    Read more.

The role of MHC Class II RT1B and immune response post brain injury The major histocompatibility complex (MHC) is responsible for binding peptide fragments arising from pathogens in order to display them on the cell surface for recognition from immune cells.  Once recognized, the foreign pathogen is typically evade...    Read more.

Major Histocompatibility Complex (MHC) Class I The products of MHC genes are antigen-presenting molecules (APMs) designed for antigen fragment (peptide) presentation to the T-cell receptor. In particular, MHC Class I molecules play a key role in the immune system by presenting endogenously synthes...    Read more.

Harnessing Natural Killer Cell Activity for Anti-Tumor Immunotherapy By Victoria Osinski, PhDWhat’s “Natural” About Natural Killer (NK) Cells?For immunologists, the term cytotoxicity often conjures up images of an army of antigen specific CD8+ T cells deploying to ...    Read more.

Read more MHC Class I related blogs.