Infantile Severe Myoclonic Epilepsy: Disease Bioinformatics
Epilepsy is defined as a diverse set of neurological disorders characterized by seizures. These seizures occur due to abnormal electrical activity in the brain. Factors that may lead to epilepsy include, but are not limited to, brain trauma, gene mutations, strokes, brain cancer, and extensive drug and alcohol use. Seizures occur due to a large release of glutamate, which causes a spread of excitation throughout the brain, which propagates the electrical signal and can lead to neuronal death. Myoclonic infantile epilepsy is characterized by seizures that contain rapid, jerk-like movements that can affect the face and limbs. Myoclonic seizures occur during wakefulness. In infants, myoclonic seizures can be caused by include brain malformations, inborn errors of metabolism, and neurogenetic disorders. The severity of the seizures can vary, and the severe episodes can lead to the child falling and undergoing violent convulsions. About 50 million people have epilepsy, with 80% of that population located in developing countries. It is possible to control epilepsy with medicine, but many cases may require surgery in order to relieve symptoms.
Top Research Reagents
We have 582 products for the study of Infantile Severe Myoclonic Epilepsy that can be applied to Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.
Infantile Severe Myoclonic Epilepsy is also known as Dravet Syndrome, Dravet Syndromes, Severe Infantile Myoclonic Epilepsy, Severe Myoclonic Epilepsy In Infancy, Severe Myoclonic Epilepsy Of Infancy.
![Immunocytochemistry/Immunofluorescence: Cip4 Antibody (1A9) [H00009322-M01] - Analysis of monoclonal antibody to TRIP10 on HeLa cell . Antibody concentration 10 ug/ml.](https://images.novusbio.com/fullsize/Cip4-Antibody-1A9-Immunocytochemistry-Immunofluorescence-H00009322-M01-img0002.jpg)
![Immunoprecipitation: Cip4 Antibody (1A9) [H00009322-M01] - Analysis of TRIP10 transfected lysate using anti-TRIP10 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with TRIP10 MaxPab rabbit polyclonal antibody.](https://images.novusbio.com/fullsize/Cip4-Antibody-1A9-Immunoprecipitation-H00009322-M01-img0003.jpg)
![Western Blot: GABA-A R gamma 2 Antibody [NB300-190] - Mouse whole brain lysate showing specific immunolabeling of the ~46 kDa gamma-2-subunit of GABAa -R.](https://images.novusbio.com/fullsize/GABA-A-R-gamma-2-Antibody-Western-Blot-NB300-190-img0002.jpg)
![Immunohistochemistry: GABA-A R gamma 2 Antibody [NB300-190] - Immunostaining of mouse retina showing specific labeling of the GABAa gamma-2 subunit in green, calbindin in red and DNA in blue. Photo courtesy of Dr. Arlene Hirano, UCLA.](https://images.novusbio.com/fullsize/GABA-A-R-gamma-2-Antibody-Immunocytochemistry-Immunofluorescence-NB300-190-img0001.jpg)
![Western Blot: Kv7.3 Antibody [NBP1-74102] - Lanes: 100 ug CHO cell lysate Primary Antibody Dilution: 1 : 1000 Secondary Antibody: Goat anti-rabbit HRP Secondary Antibody Dilution: 1 : 25000 Gene name: Kcnq3 Submitted by: Anonymous.](https://images.novusbio.com/fullsize/Kv7.3-Antibody-Western-Blot-NBP1-74102-img0004.jpg)
![Western Blot: Kv7.3 Antibody [NBP1-74102] - Kv7.3 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Heart.](https://images.novusbio.com/fullsize/Kv7.3-Antibody-Western-Blot-NBP1-74102-img0003.jpg)
![Western Blot: DHPS Antibody [NBP1-82648] - Analysis in control (vector only transfected HEK293T lysate) and DHPS over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).](https://images.novusbio.com/fullsize/DHPS-Antibody-Western-Blot-NBP1-82648-img0008.jpg)
![Immunocytochemistry/Immunofluorescence: DHPS Antibody [NBP1-82648] - Staining of human cell line U-2 OS shows localization to nucleoplasm, plasma membrane & cytosol. Antibody staining is shown in green.](https://images.novusbio.com/fullsize/DHPS-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-82648-img0007.jpg)
![Western Blot: Peripherin 2/PRPH2 Antibody [NBP1-86687] - Analysis in control (vector only transfected HEK293T lysate) and PRPH2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).](https://images.novusbio.com/fullsize/Peripherin-2-PRPH2-Antibody-Western-Blot-NBP1-86687-img0006.jpg)
![Immunohistochemistry-Paraffin: Peripherin 2/PRPH2 Antibody [NBP1-86687] - Staining of human liver shows no positivity in hepatocytes as expected.](https://images.novusbio.com/fullsize/Peripherin-2-PRPH2-Antibody-Immunohistochemistry-Paraffin-NBP1-86687-img0010.jpg)
![Immunohistochemistry-Paraffin: Dehydrodolichyl Diphosphate Synthase Antibody [NBP1-87964] - Staining of human Skeletal muscle shows very weak cytoplasmic positivity in myocytes.](https://images.novusbio.com/fullsize/Dehydrodolichyl-Diphosphate-Synthase-Antibody-Immunohistochemistry-Paraffin-NBP1-87964-img0006.jpg)
![Immunohistochemistry-Paraffin: Dehydrodolichyl Diphosphate Synthase Antibody [NBP1-87964] - Staining of human Epididymis shows strong membranous and cytoplasmic positivity in glandular cells.](https://images.novusbio.com/fullsize/Dehydrodolichyl-Diphosphate-Synthase-Antibody-Immunohistochemistry-Paraffin-NBP1-87964-img0003.jpg)
![Western Blot: SULT1A1 Antibody (9B7) [NBP2-03227] Analysis of extracts (35ug) from 9 different cell lines by using anti-SULT1A1 monoclonal antibody.](https://images.novusbio.com/fullsize/SULT1A1-Antibody-9B7-Western-Blot-NBP2-03227-img0009.jpg)
![Immunocytochemistry/Immunofluorescence: SULT1A1 Antibody (9B7) [NBP2-03227] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY SULT1A1.](https://images.novusbio.com/fullsize/SULT1A1-Antibody-9B7-Immunocytochemistry-Immunofluorescence-NBP2-03227-img0008.jpg)
![Western Blot: GBGT1 Antibody [NBP2-14040] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted)](https://images.novusbio.com/fullsize/GBGT1-Antibody-Western-Blot-NBP2-14040-img0002.jpg)
![Immunohistochemistry-Paraffin: GBGT1 Antibody [NBP2-14040] - Staining of human colon shows strong cytoplasmic positivity in glandular cells.](https://images.novusbio.com/fullsize/GBGT1-Antibody-Immunohistochemistry-Paraffin-NBP2-14040-img0001.jpg)
![Immunohistochemistry-Paraffin: SCN3A Antibody [NBP2-34003] - Staining of human lateral ventricle shows strong cytoplasmic positivity in neurons.](https://images.novusbio.com/fullsize/SCN3A-Antibody-Immunohistochemistry-Paraffin-NBP2-34003-img0001.jpg)
![Western Blot: Cytochrome P450 3A4 Antibody (3H8) [NBP2-37502] - Analysis using CYP3A4 mAb against HEK293 (1) and CYP3A4 (AA: 243-430)-hIgGFc transfected HEK293 (2) cell lysate.](https://images.novusbio.com/fullsize/Cytochrome-P450-3A4-Antibody-3H8-Western-Blot-NBP2-37502-img0003.jpg)
![Immunocytochemistry/Immunofluorescence: Cytochrome P450 3A4 Antibody (3H8) [NBP2-37502] - Analysis of HepG2 cells using CYP3A4 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.](https://images.novusbio.com/fullsize/Cytochrome-P450-3A4-Antibody-3H8-Immunocytochemistry-Immunofluorescence-NBP2-37502-img0004.jpg)
![Immunocytochemistry/Immunofluorescence: Kv7.2 Antibody [NBP2-38820] - Immunofluorescent staining of human cell line SH-SY5Y shows localization to endoplasmic reticulum.](https://images.novusbio.com/fullsize/Kv7.2-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-38820-img0003.jpg)
![Immunohistochemistry-Paraffin: Kv7.2 Antibody [NBP2-38820] - Staining of human pancreas shows low expression as expected.](https://images.novusbio.com/fullsize/Kv7.2-Antibody-Immunohistochemistry-Paraffin-NBP2-38820-img0005.jpg)
![N/A Follistatin [HRP]](https://images.novusbio.com/fullsize2/DATA_Follistatin_DFN00_ELISA_681.jpg)
![N/A Follistatin [HRP]](https://images.novusbio.com/fullsize2/DATA_Follistatin_DFN00_ELISA_682.jpg)
![Western Blot: SCN1B Antibody [NBP2-94559] - Analysis of extracts of various cell lines, using SCN1B at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 60s.](https://images.novusbio.com/fullsize/SCN1B-Antibody-Western-Blot-NBP2-94559-img0001.jpg)
![Western Blot: Cytochrome P450 2C19 Antibody [NBP3-10546] - Western blot analysis using NBP3-10546 on Human Placenta as a positive control. Antibody Titration: 0.2-1 ug/ml](https://images.novusbio.com/fullsize/Cytochrome-P450-2C19-Antibody-Western-Blot-NBP3-10546-img0001.jpg)
