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Tonic-clonic Epilepsy: Disease Bioinformatics

Epilepsy is defined as a diverse set of neurological disorders characterized by seizures. These seizures occur due to abnormal electrical activity in the brain. Factors that may lead to epilepsy include, but are not limited to, brain trauma, gene mutations, strokes, brain cancer, and extensive drug and alcohol use. Seizures occur due to a large release of glutamate, which causes a spread of excitation throughout the brain, which propagates the electrical signal and can lead to neuronal death. Tonic-clonic epilepsy is a type of generalized epilepsy, or epilepsy that affects the entire brain. Tonic-clonic epilepsy is characterized by the tonic phase of the seizure, where the person loses consciousness and has their entire body tense up, which is followed by the clonic phase of the seizure, where the person experiences convulsions which can be a little as twitches or as severe as violent shaking of the limbs. Some tonic-clonic seizures may be introduced with an aura, in which the person experiences an abnormal feeling due to a simple partial seizure that is the precursor to the tonic-clonic seizure. The SCN1A gene is affected by tonic-clonic epilepsy. About 50 million people have epilepsy, with 80% of that population located in developing countries. It is possible to control epilepsy with medicine, but many cases may require surgery in order to relieve symptoms.

Top Research Reagents

We have 2732 products for the study of Tonic-clonic Epilepsy that can be applied to Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

CD8 Antibody (53-6.7) - BSA Free

NBP1-49045

Rat Monoclonal
Species Mouse, Rat
Applications Flow, ICC/IF, IHC

3 Reviews

28 Publications

Aurora A Antibody - BSA Free

NBP1-51843

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, ICC/IF

1 Review

7 Publications

CRAT Antibody

NBP1-86616

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

2 Publications

Carbonic Anhydrase I/CA1 Antibody

NBP1-88191

$Western Blot: Carbonic Anhydrase I/CA1 Antibody [NBP1-88191] - Comparative proteome analysis of 3xTg-AD and control samples at different stages of AD. Immunoblot analysis of most regulated hits. Soluble fractions of brain proteins were analyzed from four 2-month-old control and 3xTg-AD mice animals, respectively. Hebp1 and Glo1 levels were consistently elevated in the transgenic animals as compared to wild type controls. Ca1 levels were reduced in transgenic animals. Image collected and cropped by CiteAb from the following publication (https://elifesciences.org/articles/47498), licensed under a CC-BY license.$