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Cornelia De Lange Syndrome: Disease Bioinformatics

Research of Cornelia De Lange Syndrome has been linked to Congenital Abnormality, Cytogenetic Abnormality, Growth Retardation, Microcephaly, Trisomy. The study of Cornelia De Lange Syndrome has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Cornelia De Lange Syndrome include Sister Chromatid Cohesion, Chromosome Segregation, Dna Repair, Pathogenesis, Interphase. These pathways complement our catalog of research reagents for the study of Cornelia De Lange Syndrome including antibodies and ELISA kits against CCCTC-BINDING FACTOR, NOTCH, DU, CHAT, IGF2.

Top Research Reagents

We have 1627 products for the study of Cornelia De Lange Syndrome that can be applied to Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

c-Myc Antibody (9E10) - BSA Free
NB600-302
Western Blot: c-Myc Antibody (9E10) [NB600-302] - CtIP is phosphorylated by CDKs at multiple sites. Myc-BRCA1 and/or HA-CtIP WT or indicated mutants were expressed in 293T cells and co-immunoprecipitation was performed. Image collected and cropped by CiteAb from the following publication (//doi.org/10.1371/journal.pgen.1003277) licensed under a CC-BY license.Immunohistochemistry-Paraffin: c-Myc Antibody (9E10) [NB600-302] - c-Myc was detected in immersion fixed paraffin-embedded sections of human breast cancer using anti-human mouse monoclonal antibody (Catalog # NB600-302, clone 9E10) at 1:50 dilution overnight at 4 C. Tissue was stained using the VisuCyte anti-mouse HRP polymer detection reagent (Catalog # VC001) with DAB chromogen (brown) and counterstained with hematoxylin (blue). <br/>Images may not be copied, printed or otherwise disseminated without express written permission of Novus Biologicals a bio-techne brand.

Mouse Monoclonal
Species Human, Mouse, Bovine
Applications WB, Simple Western, ELISA

     4 Reviews

46 Publications
SMC1 Antibody
NB100-204
Immunohistochemistry-Paraffin: SMC1 Antibody [NB100-204] - FFPE section of mouse colon carcinoma CT26. Antibody: Affinity purified rabbit anti-SMC1 used at a dilution of 1:5,000 (0.2ug/ml). Detection: DABImmunohistochemistry-Paraffin: SMC1 Antibody [NB100-204] - FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-SMC1 used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, ELISA

36 Publications
STAG2 Antibody (3C6)
H00010735-M01
Western Blot: STAG2 Antibody (3C6) [H00010735-M01] - STAG2 monoclonal antibody (M01), clone 3C6 Analysis of STAG2 expression in Hela S3 NE.Immunocytochemistry/Immunofluorescence: STAG2 Antibody (3C6) [H00010735-M01] - Analysis of monoclonal antibody to STAG2 on HeLa cell. Antibody concentration 10 ug/ml.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ELISA, ICC/IF

     1 Review

1 Publication
Choline Acetyltransferase/ChAT Antibody
NBP1-30052
Western Blot: Choline Acetyltransferase/ChAT Antibody [NBP1-30052] - The decrease in protein expressions of c-kit, Choline Acetyltransferase/ChAT, nNOS and Cx43 in the colon of elderly humans. Expressions of c-kit, ChAT, nNOS and Cx43 proteins in colonic muscle layers detached from youth and older adults were examined by western blotting (n=4 per group), and similar reduction was observed. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/30530917/) licensed under a CC-BY license.Immunocytochemistry/Immunofluorescence: Choline Acetyltransferase/ChAT Antibody [NBP1-30052] - Representative images of lumbar spinal cord sections at 130 days immunostained with Choline Acetyltransferase/ChAT. Scale bar, 200 um. Image collected and cropped by CiteAb from the following publication (https://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201808888), licensed under a CC-BY license.

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

24 Publications
ESCO2 Antibody
NB100-87021
Western Blot: ESCO2 Antibody [NB100-87021] - Detection of Human ESCO2 by Western Blot. Samples: Whole cell lysate (50, 15, 5 ug) from HeLa cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-ESCO2 antibody NB100-87021 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.Immunoprecipitation: ESCO2 Antibody [NB100-87021] - Detection of human ESCO2 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-ESCO2 antibody NB100-87021 (lot 2) used for IP at 6 ug per reaction. ESCO2 was also immunoprecipitated by a previous lot of this antibody (lot 1) and rabbit anti-ESCO2 antibody from Company B. For blotting immunoprecipitated ESCO2, NB100-87021 was used at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Rabbit Polyclonal
Species Human
Applications WB, IP

4 Publications
NIPBL Antibody
NBP1-85110
Immunocytochemistry/Immunofluorescence: NIPBL Antibody [NBP1-85110] - Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.Immunohistochemistry-Paraffin: NIPBL Antibody [NBP1-85110] - Staining of human small intestine shows moderate nuclear positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

1 Publication
SA1 Antibody
NBP1-87097
Western Blot: SA1 Antibody [NBP1-87097] - Analysis in U-138MG cells transfected with control siRNA, target specific siRNA probe #1 and #2,. Remaining relative intensity is presented. Loading control: Anti-GAPDH.Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

SCC112 Antibody
NBP1-87904
Immunohistochemistry-Paraffin: SCC112 Antibody [NBP1-87904] - Staining of human cerebral cortex, colon, kidney and lymph node using Anti-PDS5A antibody NBP1-87904 (A) shows similar protein distribution across tissues to independent antibody NBP2-38313 (B).Western Blot: SCC112 Antibody [NBP1-87904] - Analysis using Anti-PDS5A antibody NBP1-87904 (A) shows similar pattern to independent antibody NBP2-38313 (B).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

1 Publication
SH2D3C Antibody
NBP2-13306
Western Blot: SH2D3C Antibody [NBP2-13306] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG spImmunohistochemistry-Paraffin: SH2D3C Antibody [NBP2-13306] - Staining in human spleen and pancreas tissues using anti-SH2D3C antibody. Corresponding SH2D3C RNA-seq data are presented for the same tissues.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

Rad21 Antibody
NBP2-20053
Immunocytochemistry/Immunofluorescence: Rad21 Antibody [NBP2-20053] - HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Rad21 stained by Rad21 antibody diluted at 1:1000. Red: phalloidin, a cytoskeleton marker, diluted at 1:100. Immunohistochemistry-Paraffin: Rad21 Antibody [NBP2-20053] - Rat kidney. Rad21 stained by Rad21 antibody diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

APRIN Antibody
NB100-755
Western Blot: APRIN Antibody [NB100-755] - Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit antiPds5b antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 secondsImmunohistochemistry-Paraffin: APRIN Antibody [NB100-755] - Section of human lung small cell carcinoma. Antibody: Affinity purified rabbit anti- Pds5B used at a dilution of 1:200 (1ug/ml). Detection: DAB

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

5 Publications
Pappalysin-1/PAPP-A Antibody [Unconjugated]
AF2487
Western blot shows lysate of human pregnant sera. PVDF membrane was probed with 0.1 µg/mL of Goat Anti-Human Pappalysin-1/PAPP-A Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2487) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, IP

5 Publications
ERMAP Antibody [Unconjugated]
AF4928
K562 human chronic myelogenous leukemia cell line was stained with Goat Anti-Human ERMAP Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4928, filled histogram) or control antibody (Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Human
Applications WB, Flow, CyTOF-ready

IGF-II/IGF2 [Unconjugated]
292-G2
Recombinant Human IGF-II/IGF2 (Catalog # 292‑G2) stimulates cell proliferation in the MCF-7 human breast cancer cell line. The ED<sub>50</sub> for this effect is 1.5‑6 ng/mL.1 μg/lane of Recombinant Human IGF‑II/IGF2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 7 kDa.


Species Human
Applications BA

48 Publications
CTCF Antibody (CL0307)
NBP2-52911
Western Blot: CTCF Antibody (CL0307) [NBP2-52911] - Lane 1: Marker [kDa], Lane 2: Human cell line U-251 MGImmunocytochemistry/Immunofluorescence: CTCF Antibody (CL0307) [NBP2-52911] - Staining of MCF7 cells using the Anti-CTCF monoclonal antibody, showing specific staining in the nucleoplasm in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available).

Mouse Monoclonal
Species Human
Applications WB, ICC/IF, IHC

     1 Review

Recombinant Human MAU2 GST (N-Term) Protein
H00023383-P01
12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human
Applications WB, ELISA, PA

SMC3 Antibody
NB100-207
Western Blot: SMC3 Antibody [NB100-207] - Whole cell lysate (10 ug) from HEK293T, HeLa, Jurkat, LNCaP, U2OS, A-549, TCMK-1, and NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinitypurified rabbit anti-SMC3 antibody used for WB at 0.04 ug/ml. Detection:Chemiluminescence with an exposure time of 3 seconds.Immunohistochemistry-Paraffin: SMC3 Antibody [NB100-207] - Section of mouse renal cell carcinoma. Antibody: Affinity purified rabbit anti-SMC3 used at 1:5,000 (0.2ug/ml). Detection: DAB

Rabbit Polyclonal
Species Human, Mouse, C. elegans
Applications WB, IHC, IHC-P

9 Publications

Related Genes

Cornelia De Lange Syndrome has been researched against:

Related Pathways

Cornelia De Lange Syndrome has been linked to:

Related Diseases

Cornelia De Lange Syndrome has been studied in relation to diseases such as:

Related PTMs

Cornelia De Lange Syndrome has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Cornelia De Lange Syndrome is also known as cornelia de lange syndrome, de lange syndrome, brachmann de lange syndrome, typus degenerativus amstelodamensis, de lange syndrome (disorder), des syndrome.