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Age Related Macular Degeneration: Disease Bioinformatics

Research of Age Related Macular Degeneration has been linked to Pathologic Neovascularization, Choroidal Neovascularization, Retinal Diseases, Blind Vision, Exudative Age-related Macular Degeneration. The study of Age Related Macular Degeneration has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Age Related Macular Degeneration include Pathogenesis, Aging, Angiogenesis, Localization, Cell Death. These pathways complement our catalog of research reagents for the study of Age Related Macular Degeneration including antibodies and ELISA kits against VEGFA, AMD1, RPE, CFH, ABCA4.

Top Research Reagents

We have 3472 products for the study of Age Related Macular Degeneration that can be applied to Chromatin Immunoprecipitation, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

Bestrophin 1 Antibody (E6-6) - BSA Free
NB300-164
Western Blot: Bestrophin 1 Antibody (E6-6) - BSA Free [NB300-164] - Western blot analysis of the normal and mutant human Best1 protein in transiently transfected MDCK cells. Best1 proteins are detectable as a 68 kDa band in all transfected cells, but not in non-transfected controls (MDCK lane). Actin bands are shown to indicate equal loading of cell lysates. Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/7/15121), licensed under a CC-BY license.Immunocytochemistry/Immunofluorescence: Bestrophin 1 Antibody (E6-6) - BSA Free [NB300-164] - X-Z confocal single image scan of transiently transfected cells with different BEST1 cDNA constructs showing mislocalization of mutants Y85H, Q96R, L100R and Y227N. Cells were stained for Best1 (green), beta-catenin (red) and nuclei (blue). Scale bar = 10 um. Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1422-0067/14/7/15121), licensed under a CC-BY license.

Mouse Monoclonal
Species Human, Mouse, Porcine
Applications WB, ICC/IF, IHC

     1 Review

49 Publications
ABCA4 Antibody (3F4)
NBP1-30032
Immunohistochemistry-Frozen: ABCA4 Antibody (3F4) [NBP1-30032] - IHC-Fr of normal feline retina with antibodies ABCA4 3F4 (red) and HCAR (green). ABCA4 antibody (1:1000) labels outer segments of photoreceptors and HCAR antibody labels cones. IHC-Fr image submitted by a verified customer review.Immunohistochemistry: ABCA4 Antibody (3F4) [NBP1-30032] - staining of adult mouse retina showing specific immunolabeling of the ABCA4 protein. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA.

Mouse Monoclonal
Species Human, Mouse, Bovine
Applications WB, ICC/IF, IHC

     1 Review

5 Publications
COX5A Antibody
NBP1-32550
Western Blot: COX5A Antibody [NBP1-32550] - Various whole cell extracts (30 ug) were separated by 15% SDS-PAGE, and the membrane was blotted with COX5A antibody [N1C3] diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.Immunocytochemistry/Immunofluorescence: COX5A Antibody [NBP1-32550] - A431.

Rabbit Polyclonal
Species Human, Mouse, Zebrafish
Applications WB, ICC/IF, IHC

3 Publications
RPE Antibody
NBP1-56853
Western Blot: RPE Antibody [NBP1-56853] - Human Muscle lysate, concentration 0.2-1 ug/ml.Immunohistochemistry-Paraffin: RPE Antibody [NBP1-56853] - Antibody 0 Formalin Fixed Paraffin Embedded Tissue: Human Adult Liver Observed Staining: Cytoplasm but only in connective tissue cells in the interlobular septum, very low tissue distribution Primary Antibody

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

AMD1 Antibody
NBP1-87094
Immunocytochemistry/Immunofluorescence: AMD1 Antibody [NBP1-87094] - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.Immunohistochemistry-Paraffin: AMD1 Antibody [NBP1-87094] - Staining of human placenta shows distinct nuclear positivity in trophoblastic cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

Complement Factor B Antibody
NBP1-89985
Immunocytochemistry/Immunofluorescence: Complement Factor B Antibody [NBP1-89985] - Staining of human cell line ASC TERT1 shows localization to endoplasmic reticulum. Antibody staining is shown in green.Immunohistochemistry-Paraffin: Complement Factor B Antibody [NBP1-89985] - Staining of human prostate shows strong cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human, Rat
Applications WB, Simple Western, ICC/IF

7 Publications
Frataxin Antibody (OTI1C12)
NBP2-01743
Western Blot: Frataxin Antibody (1C12) [NBP2-01743] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Frataxin (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-Frataxin.Immunocytochemistry/Immunofluorescence: Frataxin Antibody (1C12) [NBP2-01743] Staining of COS7 cells transiently transfected by pCMV6-ENTRY Frataxin.

Mouse Monoclonal
Species Human
Applications WB, Flow, ICC/IF

Plexin A2 Antibody [Unconjugated]
AF5486
Western blot shows lysates of bEnd.3 mouse endothelioma cell line and rat embryonic cortical neuron cells. PVDF Membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat Plexin A2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5486) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=<P align=left>bEnd.3 mouse endothelioma cell line was stained with Goat Anti-Human/Mouse/Rat Plexin A2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5486, filled histogram) or isotype control antibody (Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, Flow

5 Publications
Complement Component C3d Antibody [Unconjugated]
AF2655
Complement Component C3d was detected in perfusion fixed frozen sections of mouse kidney using Goat Anti-Mouse Complement Component C3d Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2655) overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # <A class=NoLineLink href= Complement Component C3d was detected in perfusion fixed paraffin-embedded sections of rat kidney using Goat Anti-Mouse Complement Component C3d Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2655) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # <a class=

Goat Polyclonal
Species Mouse, Rat
Applications WB, IHC

54 Publications
Complement Component C2 Antibody [Unconjugated]
AF1936

Goat Polyclonal
Species Human
Applications WB, IP

1 Publication
Complement Factor H Antibody [Unconjugated]
AF4779
Complement Factor H was detected in immersion fixed paraffin-embedded sections of human liver using Goat Anti-Human Complement Factor H Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4779) at 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, IHC

     1 Review

2 Publications
HTRA1/PRSS11 Antibody (275615) [Unconjugated]
MAB2916
Western blot shows lysates of human placenta tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human HTRA1/PRSS11 Monoclonal Antibody (Catalog # MAB2916) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <a class=HtrA1 Protein Expression in hBC cell lines.Cells (as indicated) were extracted into nuclear (N) and cytoplasmic (C) fractions as described (Materials & Methods), and proteins were analyzed by Immunoblot analyses using the polyclonal antibody against human HtrA1. beta -actin was used as a loading control, and DEK was used to assess the nuclear/cytoplasmic fractionation (DEK is exclusively nuclear). The larger Mr bands seen in the MCF12A and MCF10A/Flp cell lines are consistent with dimers, trimers, etc., although this was not confirmed. MCF10A/Flp is the parental Flp-in cell line which was used to produce the various MCF10A/siRNA or Htra1 cell lines. Results are from a representative experiment. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/22761798), licensed under a CC-BY license. Not internally tested by R&D Systems.

Mouse Monoclonal
Species Human
Applications WB, IP

13 Publications
FACA/FANCA Antibody
NB100-2564
Western Blot: FACA/FANCA Antibody [NB100-2564] - Detection of FANC A in transfected COS1 cell lysate.

Rabbit Polyclonal
Species Human
Applications WB

1 Publication
Serpin F1/PEDF [Biotin]
DY1177-05
N/A Serpin F1/PEDF [Biotin]


Species Human
Applications ELISA

18 Publications
VEGF [HRP]
DVE00
N/A VEGF [HRP]N/A VEGF [HRP]


Species Human
Applications ELISA

676 Publications
LIGHT/TNFSF14 [Unconjugated]
664-LI
<P align=left>Recombinant Human LIGHT/TNFSF14 (Catalog # 664-LI) stimulates cell proliferation in HUVEC human umbilical vein endothelial cells. The ED<SUB>50</SUB> is 1-4 ng/mL.</P><p align=


Species Human
Applications BA

21 Publications
TNF-alpha [Unconjugated]
210-TA
Recombinant Human TNF-alpha (Catalog # 210-TA) has a molecular weight (MW) of 53.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a homotrimer.  MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).Recombinant Human TNF-alpha (Catalog # 210‑TA) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED<sub>50</sub> for this effect is 25‑100 pg/mL.


Species Human
Applications BA

     3 Reviews

807 Publications
ARMS2 Antibody
NBP1-07010

Rabbit Polyclonal
Species Human, Rat, Primate
Applications WB, ELISA, ICC/IF

     1 Review

ERG Antibody - BSA Free
NBP2-60655
Western Blot: ERG Antibody [NBP2-60655] - Total protein from Human THP-1, Jurkat and K562 cells was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2.0 ug/ml anti-ERG in blocking buffer and detected with an anti-rabbit HRP secondary antibody using chemiluminescence.Immunocytochemistry/Immunofluorescence: ERG Antibody [NBP2-60655] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-ERG at 5 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:500 dilution. Alpha tubulin (DM1A) NB100-690 was used as a co-stain at a 1:1000 dilution and detected with an anti-mouse Dylight 550 (Red) at a 1:500 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

Kv11.1 Antibody - Azide and BSA Free
NBP3-03109
Western Blot: Kv11.1 Antibody [NBP3-03109] - Analysis of extracts of various cell lines, using Kv11.1 antibody at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL EnhanImmunohistochemistry-Paraffin: Kv11.1 Antibody [NBP3-03109] - Human lung cancer using KCNH2 antibody at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P


Related Genes

Age Related Macular Degeneration has been researched against:

Related Pathways

Age Related Macular Degeneration has been linked to:

Related Diseases

Age Related Macular Degeneration has been studied in relation to diseases such as:

Related PTMs

Age Related Macular Degeneration has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Age Related Macular Degeneration is also known as age related macular degeneration, age-related macular degeneration, senile macular retinal degeneration, macular degeneration, senile, macular degeneration, amd.