Serpin A5/Protein C Inhibitor Products

Description

PAI-1, PAI-2 and PAI-3 (plasminogen activator inhibitor-1, -2 and -3) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 regulate uPA (urokinase-type plasminogen activator) and TPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. PAI-3 inhibits plasminogen activators as well as activated protein C. PAI-3 is secreted in plasma, but is also expressed in liver.

Bioinformatics

Entrez	5104 Human
Uniprot	AAH08915 Human NM_000624 Human P05154 Human P70458.2 Mouse
Product By Gene ID	5104
Alternate Names	Acrosomal serine protease inhibitor antitrypsin), member 5 member 5 PAI-3 PAI3PLANH3 PCIplasminogen activator inhibitor III Plasminogen activator inhibitor 3 plasminogen activator inhibitor-3 PROCIplasma serine protease inhibitor Protein C inhibitor serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase Serpin A5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin) SERPNA5

Research Areas for Serpin A5/Protein C Inhibitor

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Cancer