Plasminogen Products

Description

Plasminogen is a plasma protein synthesised mostly in the liver. Plasma concentration is usually in the range of 70 to 200mg/L. Plasminogen is activated by tissue plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Angiostatin, an internal fragment of plasminogen, is a potent inhibitor of angiogenesis, which selectively inhibits endothelial cell proliferation. Angiostatin potently inhibits tumor growth and can maintain metastatic and primary tumors in a dormant state. It is defined by a balance of proliferation and apoptosis of the tumor cells and is composed of plasminogen first four cringle structures. This molecule is generated by proteolytic cleavage of plasminogen.

Bioinformatics

Entrez	18815 Mouse 5340 Human 85253 Rat
Uniprot	AAA50168 Mouse AAH60513 Human NM_000301 Human NP_000292 Human NP_000292.1 Human P00747 Human P20918 Mouse
Product By Gene ID	5340
Alternate Names	DKFZp779M0222 EC 3.4.21 EC 3.4.21.7 plasmin plasminogen

Research Areas for Plasminogen

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cell Cycle and Replication