Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IP
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
MEKK2 is a Ser/Thr protein kinase belonging to the MEKK/STE11 subgroup of the MAP/ERK kinase kinase family (1). Closely related to MEKK3, MEKK2 is expressed in a multitude of tissues. MEKK2 directly phosphorylates and activates Ikappa B kinases and has been found to bind and activate protein kinase C-related kinase 2 (2). MEKK2 has also been known to activate JNK1/2, ERK1/2, p38, and ERK5 MAPK in vitro (3). MEKK2 interacting protein (Mip1) regulates MEKK2 expression (4).
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
10746 |
| Alternate Names |
- EC 2.7.11.25
- MAP/ERK kinase kinase 2
- MAPK/ERK kinase kinase 2
- MAPKKK2
- MEK kinase 2
- MEKK 2
- MEKK2
- MEKK2B
- mitogen-activated protein kinase kinase kinase 2
|
Research Areas for MEKK2
Find related products by research area and learn more about each of the different research areas below.
AngiogenesisCancerProtein Kinase
