HGF Products

Description

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq]

Bioinformatics

Entrez	15234 Mouse 3082 Human
Uniprot	AAH22308 Human M73239 Human NM_000601 Human NP_000592 Human NP_000592.3 Human P14210 Human P14210 Human
Product By Gene ID	3082
Alternate Names	deafness, autosomal recessive 39 DFNB39 EC 3.4.21 EC 3.4.21.7 fibroblast-derived tumor cytotoxic factor F-TCF hepatocyte growth factor (hepapoietin A; scatter factor) Hepatopoeitin-A HGFB HPTAhepatocyte growth factor lung fibroblast-derived mitogen Scatter factor SFhepatopoeitin-A

Research Areas for HGF

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication

Related HGF Blog Posts

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The role of HIF-2 alpha in the progression and therapy of clear cell renal cell carcinoma HIF-2 alpha, also known as hypoxia-inducible factor 2, endothelial PAS domain protein-1, and member of PAS superfamily 2 is part of the HIF family of proteins.  The HIF family is composed of HIF-1, HIF-2 and HIF-3, where HIF-2 is a dimeric protein ...    Read more.

Application Focus: New Methods for iPSC Differentiation, Inducing a Mammary Fate Discovery of the Key to PluripotencyInduced pluripotent stem cells (iPSCs) may be generated from a wide range of fully differentiated cells, and under optimal conditions may be prompted to differentiate into virtu...    Read more.

VEGFR-2 - A highly active kinase VEGFR-2 is a family member of the vascular endothelial growth factor (VEGF) family of membrane receptor tyrosine kinases. It is a key regulator of the process of angiogenesis that takes place during fundamental developmental processes such as embry...    Read more.

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