DNA Ligase IV Products

Description

LIG4 encodes a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome.

Bioinformatics

Entrez	3981 Human
Uniprot	AAH37491 Human ABM86612.1 Human NM_002312 Human NM_206937 Human NP_001091738 Human P49917 Human
Product By Gene ID	3981
Alternate Names	DNA joinase DNA ligase 4 DNA ligase IV DNA repair enzyme EC 6.5.1.1 ligase IV, DNA, ATP-dependent Polydeoxyribonucleotide synthase [ATP] 4 polynucleotide ligase sealase

Research Areas for DNA Ligase IV

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
DNA Double Strand Break Repair
DNA Repair
Non-homologous end-joining