ACSL5 Products

Description

Long-chain-fatty-acid--CoA ligase 5, or ACSL5, is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. These proteins play an important role in both synthesis of cellular lipids and degradation via beta-oxidation. Like other isozymes of this family, ALCS5 converts free long-chain fatty acids into fatty acyl-CoA esters. Specifically, ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage.

This isozyme is highly expressed in uterus and spleen, and in trace amounts are found in normal brain. It also has significantly increased expression in malignant gliomas, where the protein functions in mediating fatty acid-induced glioma cell growth. Therefore, ALCS5 is thought to have a key role in the survival of glioma cells and may be a potential target for novel cancer treatments. Three transcript variants encoding two different isoforms have been found for this gene.

Bioinformatics

Entrez	51703 Human
Uniprot	NM_016234 Human NP_057318 Human NP_057318.2 Human Q9ULC5 Human
Product By Gene ID	51703
Alternate Names	ACS2 ACS5FACL5 for fatty acid coenzyme A ligase 5 acyl-CoA synthetase long-chain family member 5 EC 6.2.1 EC 6.2.1.3 FACL5fatty acid coenzyme A ligase 5 fatty-acid-Coenzyme A ligase, long-chain 5 LACS 5 Long-chain acyl-CoA synthetase 5 long-chain fatty acid coenzyme A ligase 5 long-chain-fatty-acid--CoA ligase 5

Research Areas for ACSL5

Find related products by research area and learn more about each of the different research areas below.

Cancer
Lipid and Metabolism