Species: Mu
Applications: WB, Flow, IHC
Host: Rat Monoclonal
Species: Hu
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Description
ATP-binding cassette sub-family A member 7 (ABCA7), is a member of the ATP-binding cassette sub-family A. ABCA7 is thought to have a role in phagocytosis apoptotic cells macrophages.
ABCA-7 is highly homologous to ABCA1, and also mediates cellular cholesterol and phospholipid release by apolipoproteins. The ABCA7 gene is regulated by sterol in the opposite direction to ABCA1 through SRE/SREBP2. The expression of ABCA7 by this regulation is associated with phagocytic activity. As well, it binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. It also may mediate cholesterol efflux.
ABCA7 antibodies are useful for studies of cholesterol formation and lipid processing mechanisms.
Bioinformatics
| Entrez |
Human
Mouse
|
| Uniprot |
Human
Mouse
|
| Product By Gene ID |
10347 |
| Alternate Names |
- ABCA-SSN
- ABCXATP-binding cassette sub-family A member 7
- ATP-binding cassette, sub-family A (ABC1), member 7
- Autoantigen SS-N
- EC 2.2.1.1
- EC 3.6.3
- EC 3.6.3.41
- FLJ40025
- Macrophage ABC transporter
|
