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NK cells

Chemotherapy-induced metastasis: An unexpected foe?

CD16 - Find me on macrophages, neutrophils and NK cells

CD16 is a lymphocyte Fc gamma type III low-affinity receptor for IgG and is represented by two similar genes, CD16A (Fc gamma RIII A) and CD16B (Fc gamma RIIIB). CD16A exists as a heterooligomeric polypeptide-anchored form in macrophages and NK cells. CD16B exists as a monomeric glycosylphosphatidylinositol (GPI)-anchored form in neutrophils. CD16 binds IgG in the form of immune complexes or free antibody. It exhibits preferential binding to IgG1 and IgG3 isotypes, with minimal binding of IgG2 and IgG4.

Analyzing Blood Diseases by Flow Cytometry

Studies on leukemias and other blood related malignancies is one of the most relevant investigational and medicinal applications of flow cytometry. In the bone marrow, normal blood cells undergo a progressive series of differentiation and branch off as myeloid, B and T cells. Hematological disorders can arise at any stage of the cell, while the differentiating cell will express a distinctive marker depending on the stage of differentiation.