XRCC4 Products

Description

XRCC4 is encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq]

Bioinformatics

Entrez	7518 Human
Uniprot	NM_022550 Human NP_003392 Human NP_071801.1 Human Q13426 Human
Product By Gene ID	7518
Alternate Names	complementing defective, repair in Chinese hamster X-ray repair complementing defective repair in Chinese hamster cells 4 X-ray repair cross-complementing protein 4

Research Areas for XRCC4

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Double Strand Break Repair
DNA Repair
Homologous Recombination
Non-homologous end-joining
Tumor Suppressors

Related XRCC4 Blog Posts

Check out the latest blog posts on XRCC4.

Ku70: The DNA's Mr. Fix-it Ku70, known by several synonyms including X-ray repair cross-complementing, 5'-deoxyribose-5-phosphate lyase Ku70 protein 6, 70 kDa subunit of Ku antigen, XRCC6, and G22P1, is a 70 kDa protein that was shown to be involved in multiple cellular pathway...    Read more.

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