MGMT Products

Description

O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytotoxic activity of chemotherapeutic alkylating agents. This protein is also effective in protecting normal cells against the genotoxic and carcinogenic effects of DNA alkylation. The alkylating drug resistance is caused by MGMT's ability to remove DNA alkyl groups introduced in the O6 position of guanine. MGMT is expressed in highly variable amounts, depending upon the cell and tissue type, species, and cellular growth characteristics. In addition, MGMT activity varies among groups of tumors and within a particular type of tumor.

MGMT antibodes are useful tools for DNA repair studies and for some cancer research.

Bioinformatics

Entrez	17314 Mouse 25332 Rat 4255 Human
Uniprot	AAH00824 Human B4DEE8 Human NP_002403 Human P16455 Human
Product By Gene ID	4255
Alternate Names	6-O-methylguanine-DNA methyltransferase EC 2.1.1.63 methylated-DNA--protein-cysteine methyltransferase methylguanine-DNA methyltransferase O-6-methylguanine-DNA methyltransferase O6-methylguanine-DNA methyltransferase O-6-methylguanine-DNA-alkyltransferase

Research Areas for MGMT

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Chromatin Research
Direct Reversal of DNA Damage
DNA Repair
Tumor Suppressors