Smad1 Products

Description

Smad1 is encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

Bioinformatics

Entrez	17125 Mouse 25671 Rat 4086 Human
Uniprot	AAH01878 Human AAH01878.1 Human NM_001003688 Human NM_005900 Human NP_001003688.1 Human NP_005891 Human Q15797 Human
Product By Gene ID	4086
Alternate Names	BSP1 BSP-1 hSMAD1 JV4-1SMAD, mothers against DPP homolog 1 (Drosophila) MAD homolog 1 MADH1JV41 MADR1MAD, mothers against decapentaplegic homolog 1 (Drosophila) Mad-related protein 1 mothers against decapentaplegic homolog 1 mothers against decapentaplegic homolog 1 Mothers against DPP homolog 1 SMAD family member 1SMAD 1 SMAD, mothers against DPP homolog 1 Smad1 TGF-beta signaling protein 1 transforming growth factor-beta signaling protein 1

Research Areas for Smad1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Diabetes Research
Phospho-Specific

Related Smad1 Blog Posts

Check out the latest blog posts on Smad1.

Alpha-smooth muscle actin and the modulation of endothelial and epithelial cell biology Actin is essential for a wide range of cell functions, ranging from cell division and chromatin remodeling to vesicle trafficking and maintenance of cellular structure. In fact, mislocalization of actin to cell junctions during development leads t...    Read more.

Transforming Growth Factor beta Signaling in Stem Cells Transforming growth factor beta (TGF beta) signaling along with its family members have been implicated in development and maintenance of various organs. Stem cells are important contributors to this process and are characterized by their ability to s...    Read more.

Nanog is a Master Controller of ES cell Pluripotency Nanog, a homeodomain (HD) transcription factor, plays a critical role in the maintenance of embryonic stem (ES) cell self-renewal. Transcription regulator involved in inner cell mass and ES cell proliferation and self-renewal. Imposes pluripotency on ...    Read more.

Read more Smad1 related blogs.