Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Po, Bv, RM, Sh, Xp, Ze
Applications: WB, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demon-strate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
6009 |
| Alternate Names |
- GTP-binding protein Rheb
- MGC111559
- Ras homolog enriched in brainRHEB2Ras homolog enriched in brain 2
|
Related Rheb Blog Posts
Check out the latest blog posts on Rheb.
mTOR - a central regulator of cell metabolism
The mammalian target of rapamycin (mTOR) signaling pathway allows cells to monitor environmental signals like nutrient availability and oxygen levels. mTOR is a phosphoinositide 3-kinase (PI3K)-related protein that assembles into large protein comp... Read more.
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TSC1 - a negative regulator of mTOR signaling
TSC1 is a tumor suppressor gene that encodes a 130 kDa protein called hamartin. TSC1 was first identified as an oncogenic driver of Tuberous Sclerosis, a condition characterized by numerous benign tumors of the skin, brain, heart, and lungs. A mut... Read more.
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Read more Rheb related blogs.
![Western Blot Rheb Antibody (344912) [Unconjugated]](http://images.novusbio.com/fullsize2/Rheb_MAB3426_Western_Blot_6104.jpg)
![Immunocytochemistry Rheb Antibody (344912) [Unconjugated]](http://images.novusbio.com/fullsize2/Rheb_MAB3426_Immunocytochemistry__Immunofluorescence_22496.jpg)
![Immunocytochemistry Rheb Antibody (344912) [Unconjugated]](http://images.novusbio.com/fullsize2/mab3426_human-mouse-rat-rheb-mab-clone-344912-immunocytochemistry-31102022134415.jpg)
