PTEN Products

Description

PTEN is a protein tyrosine phosphatase that acts as a tumor suppressor, as a lipid phosphatase that dephosphorylates the D3 position of phosphatidylinositol 3,4,5-trisphosphate and as an antagonist of the PI3k/AKT signaling pathway (1-3). PTEN structural domains includes an N-terminal phosphatase domain, a lipid binding C2 domain and a 50-amino acid C-terminal tail that contains a PD biding sequence (5). Phosporylation of the tail of the protein will suppress its activity and modify its conformation to a

Bioinformatics

Entrez	19211 Mouse 50557 Rat 5728 Human
Uniprot	AAH05821 Human AAH05821.1 Human NP_000305 Human NP_000305.3 Human P60484 Human
Product By Gene ID	5728
Alternate Names	BZS EC 3.1.3.16,10q23del EC 3.1.3.48 EC 3.1.3.67 GLM2 MMAC1 phosphatase and tensin homolog deleted on chromosome 10 MMAC1MGC11227 Mutated in multiple advanced cancers 1 phosphatase and tensin homologDEC phosphatidylinositol-34,5-trisphosphate 3-phosphatase and dual-specificityprotein phosphatase PTEN PTEN1 TEP1MHAM

Research Areas for PTEN

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Cell Biology
Lipid and Metabolism
mTOR Pathway
Phospho-Specific
Protein Phosphatase
Signal Transduction
Transcription Factors and Regulators
Tumor Suppressors

Related PTEN Blog Posts

Check out the latest blog posts on PTEN.

The effects of curcumin on IKB Alpha and the NFkB signaling pathway The IKK complex, or inhibitor of NFkB kinase, is composed of IKK alpha and IKK beta.  These kinases are at the core of the NFkB signaling cascade.  The NFkB family is made up of transcription factors that are kept inactive in the cytoplasm through...    Read more.

PTEN Antibodies and Cancer Research Phosphatase and tensin homologue (PTEN) antibodies are important tools for cancer research. PTEN is an important tumor suppressor but, in mutated form, is also expressed in a high number of cancers. We at Novus Biologicals have a wide PTEN antibody da...    Read more.

Getting SHIP-shape Over Tumour Suppression PTEN antibodies have shown PTEN to be an important tumor suppressor and, in mutated form, a factor in cancer development. However, a recent study, led by Robert Rickert, shows that the SHIP gene may also be an important tumor suppressor in B-cell lymp...    Read more.

CAIX - One of the Best Cellular Markers of Hypoxia The protein, carbonic anhydrase IX, belongs to the carbonic anhydrase family which consists of enzymes that rapidly convert carbon dioxide and water into the end products of carbonic acid, protons, and bicarbonate ions. These enzymes play a widespread...    Read more.

Developmental regulator Daam2 promotes glial cell tumors by degrading Von Hippel-Lindau protein By Jamshed Arslan Pharm.D. Glioblastoma is an aggressive type of cancer that forms from the star-shaped glial cells of the central nervous system, called astrocytes. Intriguingly, several genes linked to glioblasto...    Read more.

Carbonic anhydrase IX (CAIX) - a reliable histochemical marker of hypoxia Carbonic anhydrase IX is a member of the carbonic anhydrase family. This family consists of catalytic enzymes capable of converting carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. This family of molecules is abundantly e...    Read more.

Neurovascular signaling for repair enhances brain metastasis By Jamshed Arslan, Pharm. D., PhD. Stroke    is a leading cause of mortality and morbidity worldwide. Cellular players – neurons, astrocytes, endothelial and stromal cells – involved in post-stroke repair t...    Read more.

Autophagy Research Update: What a difference a year makes! By Christina Towers, PhD Over the last two decades the field of autophagy has exploded! Innovative techniques, comprehensive analysis and disease-relevant models have yielded basic and clinical discoveries of conseque...    Read more.

Read more PTEN related blogs.