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![SDS-Page: Recombinant Human Tau 441 Active, P301S Mutant, Pre-formed Fibrils Protein [NBP2-76794] - DS-PAGE of ~67 kDa Human Tau Protein 2N4R P301S Preformed Fibrils (NBP2-76794). Lane 1: MW Ladder. Lane 2: Tau Protein Preformed Fibrils (NBP2-76794)](http://images.novusbio.com/fullsize/Recombinant-Human-Tau-441-Active--P301S-Mutant--Pre-formed-Fibrils-Protein-SDS-Page-NBP2-76794-img0001.jpg "SDS-Page: Recombinant Human Tau 441 Active, P301S Mutant, Pre-formed Fibrils Protein [NBP2-76794] - DS-PAGE of ~67 kDa Human Tau Protein 2N4R P301S Preformed Fibrils (NBP2-76794). Lane 1: MW Ladder. Lane 2: Tau Protein Preformed Fibrils (NBP2-76794)")
![In vitro assay: Recombinant Human Tau 441 Active, P301S Mutant, Pre-formed Fibrils Protein [NBP2-76794] - Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures such as those in tau fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift, and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) when tau Pre-formed Fibrils (NBP2-76794) are combined with tau monomers . The Pre-formed Fibrils seed the formation of new fibrils from a pool of monomers. Thioflavin T ex = 450 nm, em = 485 nm. 10 uM heparin was added to each well.](http://images.novusbio.com/fullsize/Recombinant-Human-Tau-441-Active--P301S-Mutant--Pre-formed-Fibrils-Protein-In-vitro-assay-NBP2-76794-img0002.jpg)
![Electron Microscopy: Recombinant Human Tau 441 Active, P301S Mutant, Pre-formed Fibrils Protein [NBP2-76794] - TEM of recombinant Tau 441441 (2N4R), P301S mutant Pre-formed Fibrils (PFFs). Fibrils were sonicated and stained with uranyl acetate.](http://images.novusbio.com/fullsize/Recombinant Human Tau 441 Active- P301S Mutant- Pre-formed Fibrils Protein-Electron Microscopy-NBP2-76794-img0004.jpg)
![Electron Microscopy: Recombinant Human Tau 441 Active, P301S Mutant, Pre-formed Fibrils Protein [NBP2-76794] - TEM of recombinant Tau 441441 (2N4R), P301S mutant Pre-formed Fibrils (PFFs) at 150kx magnification. HV = 80kV. Fibrils were sonicated and stained with uranyl acetate.](http://images.novusbio.com/fullsize/Recombinant-Human-Tau-441-Active--P301S-Mutant--Pre-formed-Fibrils-Protein-Electron-Microscopy-NBP2-76794-img0003.jpg)
![SDS-Page: Recombinant Human Tau 441 Active, Monomer, P301S Mutant Protein [NBP2-76795] - SDS-PAGE of ~67 kDa Human Tau Protein 2N4R P301S Monomer (NBP2-76795). Lane 1: MW ladder. Lane 2: Tau Protein Monomer (NBP2-76795)](http://images.novusbio.com/fullsize/Recombinant-Human-Tau-441-Active--Monomer--P301S-Mutant-Protein-SDS-Page-NBP2-76795-img0001.jpg "SDS-Page: Recombinant Human Tau 441 Active, Monomer, P301S Mutant Protein [NBP2-76795] - SDS-PAGE of ~67 kDa Human Tau Protein 2N4R P301S Monomer (NBP2-76795). Lane 1: MW ladder. Lane 2: Tau Protein Monomer (NBP2-76795)")
![In vitro assay: Recombinant Human Tau 441 Active, Monomer, P301S Mutant Protein [NBP2-76795] - Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in tau fibrils. Upon binding, the emission spectrum of the dye experiences a red-shift and increased fluorescence intensity. Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time in tau monomers (NBP2-76795). A greater increase in fluorescence is seen when 50 uM monomer (NBP2-76795) is combined with 10 nM PFFs , as the fibrils seed the formation of new fibrils from the pool of monomers. Thioflavin T ex = 450 nm, em = 485 nm. 10 uM heparin was added to each well.](http://images.novusbio.com/fullsize/Recombinant-Human-Tau-441-Active--Monomer--P301S-Mutant-Protein-In-vitro-assay-NBP2-76795-img0002.jpg)