VISTA/B7-H5/PD-1H Antibody (730804) [Phycoerythrin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Platelet Receptor Gi24, also known as VISTA (V-domain Ig suppressor of T cell activation), B7-H5, B7H5, Dies1 (Differentiation of ESC-1), SISP1 and C10orf54, is a 55-65 kDa member of the Ig superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162 aa extracellular region with one V-type Ig-like domain and a 96 aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment. Over aa 33-194, human Gi24 shares 70% and 67% aa identity with mouse and rat Gi24, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publication 1 - 1 of 1.

Publication using FAB71261P	Applications	Species
S Shahbaz, G Dunsmore, P Koleva, L Xu, S Houston, S Elahi Galectin-9 and VISTA Expression Define Terminally Exhausted T Cells in HIV-1 Infection J. Immunol., 2020-03-23;0(0):. 2020-03-23 [PMID: 32205423]

Array FAB71261P

• VISTA/B7-H5/PD-1H Antibodies
• VISTA/B7-H5/PD-1H Lysate
• VISTA/B7-H5/PD-1H Proteins
• VISTA/B7-H5/PD-1H Proteins and Enzymes
• VISTA/B7-H5/PD-1H ELISA