TrkB Antibody (75133) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The neurotrophins, including NGF, BDNF, NT-3, and NT-4/5 constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to the different members of the Trk family tyrosine kinase receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF, TrkB binds BDNF and NT‑4/5 and TrkC binds NT-3. All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain. Natural splice variants of the different Trks, including TrkB variants lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described. The role of the different extracellular subdomains of TrkB in mediating neurotrophin binding and discrimination is currently being investigated. At the protein sequence level, human and rat TrkB are greater than 90% identical and the proteins exhibit cross-species activity. TrkB is primarily expressed in the nervous system. However, low levels of TrkB expression have also been observed in a wide variety of tissues (pancreas, kidneys, ovary) outside the nervous system.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 5 applications: Flow Cytometry, ICC, IHC, IHC-P, Western Blot.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using MAB397	Applications	Species
Wang, J;Yu, H;Li, X;Li, F;Chen, H;Zhang, X;Wang, Y;Xu, R;Gao, F;Wang, J;Liu, P;Shi, Y;Qin, D;Li, Y;Liu, S;Ding, S;Gao, XY;Wang, ZH; A TrkB cleavage fragment in hippocampus promotes Depressive-Like behavior in mice Brain, behavior, and immunity 2024-03-29 [PMID: 38555992] (Western Blot, Mouse)	Western Blot	Mouse
Mustafa N. Okur, Burcin Duan Sahbaz, Risako Kimura, Uri Manor, Jaimin Patel, Jae‐Hyeon Park et al. Long‐term NAD+ supplementation prevents the progression of age‐related hearing loss in mice Aging Cell 7/3/2023 [PMID: 37395319]
Ramirez M, Ninoyu Y, Miller C et al. Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3 iScience 7/1/2022 [PMID: 35992071]
J Xiong, J Liao, X Liu, Z Zhang, J Adams, R Pacifici, K Ye A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin Nature Communications, 2022-08-16;13(1):4820. 2022-08-16 [PMID: 35973996] (Western Blot, Mouse)	Western Blot	Mouse
Melissa J. Marchese, Shuman Li, Bin Liu, Jun J. Zhang, Liping Feng Perfluoroalkyl Substance Exposure and the BDNF Pathway in the Placental Trophoblast Front Endocrinol (Lausanne) 7/28/2021 [PMID: 34394001]
Fleury S, Boukhatem I, Le Blanc J et al. Tissue-Specificity of Antibodies Raised Against TrkB and p75NTR Receptors; Implications for Platelets as Models of Neurodegenerative Diseases Frontiers in Immunology 2/11/2021 [PMID: 33643311]
Luo S, Su Kang S, Wang ZH et al. Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing its Antioxidative Activities in Parkinson's Disease J. Neurosci. 7/29/2019 [PMID: 31358653]
ZH Wang, J Xiang, X Liu, SP Yu, FP Manfredsso, IM Sandoval, S Wu, JZ Wang, K Ye Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBP? in Alzheimer's Disease Cell Rep, 2019-07-16;28(3):655-669.e5. 2019-07-16 [PMID: 31315045] (Western Blot, Mouse, Rat)	Western Blot	Mouse, Rat
Wang ZH, Wu W, Kang SS et al. BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT JCI Insight 8/23/2018 [PMID: 30135302]
Mikhail Stepanichev, Mikhail Onufriev, Viktor Aniol, Sofia Freiman, Hemma Brandstaetter, Stefan Winter et al. Effects of cerebrolysin on nerve growth factor system in the aging rat brain Restorative Neurology and Neuroscience 11/25/2017 [PMID: 29172008]
Sandra Pinet, Barbara Bessette, Nicolas Vedrenne, Aurélie Lacroix, Laurence Richard, Marie-Odile Jauberteau et al. TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells Oncotarget 8/2/2016 [PMID: 27385098]
Wang Y, Hersheson J, Lopez D et al. Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell Rep 6/28/2016 [PMID: 27320912]
Tanaka , Koji, Okugawa , Yoshinag, Toiyama , Yuji, Inoue , Yasuhiro, Saigusa , Susumu, Kawamura , Mikio, Araki , Toshimit, Uchida , Keiichi, Mohri , Yasuhiko, Kusunoki , Masato Brain-derived neurotrophic factor (BDNF)-induced tropomyosin-related kinase B (Trk B) signaling is a potential therapeutic target for peritoneal carcinomatosis arising from colorectal cancer. PLoS ONE, 2014-05-06;9(5):e96410. 2014-05-06 [PMID: 24801982] (IHC, Human)	IHC	Human
K. Fujita, K. Tatsumi, E. Kondoh, Y. Chigusa, H. Mogami, T. Fujii et al. Differential expression and the anti-apoptotic effect of human placental neurotrophins and their receptors Placenta 10/1/2011 [PMID: 21831423]
Rossing K, Novak N, Mommert S, Pfab F, Gehring M, Wedi B, Kapp A, Raap U Brain-derived neurotrophic factor is increased in serum and skin levels of patients with chronic spontaneous urticaria. Clin. Exp. Allergy, 2011-06-16;41(10):1392-1399. 2011-06-16 [PMID: 21676041] (IHC-P, Human)	IHC-P	Human
Li Y, Serwanski DR, Miralles CP et al. Synaptic and nonsynaptic localization of protocadherin-gammaC5 in the rat brain. J Comp Neurol;518(17):3439-63. 9/1/2010 [PMID: 20589908]
Cai J, Yang M, Poremsky E et al. Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats. Stem Cells Dev 7/1/2010 [PMID: 19824823]
Raap U, Fokkens W, Bruder M, Hoogsteden H, Kapp A, Braunstahl GJ Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis. Allergy, 2008-02-11;63(4):468-75. 2008-02-11 [PMID: 18266897] (ICC, Human)	ICC	Human
Gleissner CA, Zastrow A, Klingenberg R, Kluger MS, Konstandin M, Celik S, Haemmerling S, Shankar V, Giese T, Katus HA, Dengler TJ IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells. Eur. J. Immunol., 2007-01-01;37(1):177-92. 2007-01-01 [PMID: 17163451] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 19 Publications. Collapse Publications.

Array MAB397

• TrkB Antibodies
• TrkB Antibody Pair
• TrkB ELISA Kits
• TrkB Lysates
• TrkB Proteins
• TrkB Proteins and Enzymes
• TrkB ELISAs