TERT Antibody (2D8)

Telomerase reverse transcriptase (TERT) is a ribonucleoprotein enzyme essential for eukaryotic chromosomal termini replication that is active in progenitor as well as cancer cells, and stays inactive or show very low activity in normal somatic cells. TERT is the catalytic component of the holoenzyme complex (TERT, DKC1, WDR79/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and TERC) that implicates in telomeres elongation by acting as a reverse transcriptase adding simple sequence repeats to chromosome ends by copying a template sequence within RNA component of the enzyme. For executing its versatile functions, TERT can interact with HSP90A , PTGES3, HSPA1A, RAN , XPO1, PTPN11, NCL, SMARCA4, MCRS1, PIF1, PML and GNL3L. TERT modulates Wnt signaling and plays important roles in aging and anti-apoptosis. Telomerase activation has been implicated in cell immortalization/ carcinogenesis and defects in TERT are associated with susceptibilty to aplastic anemia, coronary artery disease (CAD), dyskeratosis congenita autosomal dominant type 2 (DKCA2), pulmonary fibrosis, and/or bone marrow failure, telomere-related, type 1 (PFBMFT1), dyskeratosis congenita autosomal recessive type 4 (DKCB4), susceptibility to pulmonary fibrosis idiopathic (IPF).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: FLOW, ICC/IF, IF/IHC, IHC-Fr, WB.

Showing Publications 1 - 9 of 9.

Publications using NB100-297	Applications	Species
Akiyama M, Ozaki K, Kawano T et al. Telomerase activation as a repair response to radiation-induced DNA damage in Y79 retinoblastoma cells. Cancer Lett 2013-07-11 [PMID: 23850566] (WB, Human)	WB	Human
Heeg S, Hirt N, Queisser A et al. EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis Cancer Sci 2011-02-01 [PMID: 21156006] (WB, Human)	WB	Human
Fabricius EM, Kruse-Boitschenko U, Khoury R et al. Localization of telomerase hTERT protein in frozen sections of basal cell carcinomas (BCC) and tumor margin tissues. Int J Oncol. 2009-12-01 [PMID: 19885561] (IHC-Fr, Human)	IHC-Fr	Human
Fabricius EM, Kruse-Boitschenko U, Khoury R et al. Immunohistochemical determination of the appropriate anti-hTERT antibodies for in situ detection of telomerase activity in frozen sections of head and neck squamous cell carcinomas and tumor margin tissues. Int J Oncol 2009-05-01 [PMID: 19360339] (IF/IHC, Human)	IF/IHC	Human
Xiao Y, Gao X, Gannot G et al. Quantitation of HER2 and telomerase biomarkers in solid tumors with IgY antibodies and nanocrystal detection. Int J Cancer;122(10):2178-86. 2008-05-15 [PMID: 18214859]
Zhang JG, Eguchi J, Kruse CA et al. Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. Clin Cancer Res;13(2 Pt 1):566-75. 2007-01-15 [PMID: 17255279] (ICC/IF, FLOW, Human)	ICC/IF, FLOW	Human
Deissler H, Deissler H, Lang GK et al. Generation and characterization of iBREC: novel hTERT-immortalized bovine retinal endothelial cells. Int J Mol Med. 2005-07-01 [PMID: 15942679] (WB, Human)	WB	Human
Masutomi, K et al. The telomerase reverse transcriptase regulates chromatin state DNA damage responses. PNAS 102(23): 8222-8227. 2005-01-01 [PMID: 15928077] (WB, Human)	WB	Human
Blasco MA, Hahn WC. Evolving views of telomerase and cancer. Trends Cell Biol;13(6):289-94. 2003-06-01 [PMID: 12791294]

Array NB100-297

• TERT Antibodies
• TERT Antibody Pack
• TERT Protein