SorLA Antibody

SORL1 is likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. It binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. SORL1 binds the receptor-associated protein (RAP). It could play a role in cell-cell interaction. SORL1 is expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. It is also found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. Moreover, it is expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 4 of 4.

Publications using NB100-785	Applications	Species
Perek B, Kowalska K et al. Infiltration of CD68+ cells correlates positively with matrix metalloproteinase 2 expression in the arteries used as aortocoronary bypass grafts. Possible clinical implications. Cardiol J 2019-06-09 [PMID: 31489609]
Linard C, Busson E, Holler V et al. Repeated autologous bone marrow-derived mesenchymal stem cell injections improve radiation-induced proctitis in pigs. Stem Cells Transl Med. 2013-11-01 [PMID: 24068742]
Huang Y, Kesselman D, Kizub D et al. Phospho-deltaNp63alpha/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure. Cell Cycle 2013-02-15 [PMID: 23343772]
Jacobsen L, Madsen P, Jacobsen C et al. Activation and functional characterization of the mosaic receptor SorLA/LR11. J Biol Chem 2001-06-22 [PMID: 11294867]

Array NB100-785

• SorLA Antibodies
• SorLA Protein
• SorLA Proteins and Enzymes