Sorbitol Dehydrogenase Antibody

Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. Sorbitol dehydrogenase catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications. The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor. It has been noted that the polyol pathway is particularly active in hyperglycemic states. Although SORD is closely related to the class I long-chain alcohol dehydrogenases, it differs in substrate specificity, catalyzing polyols such as sorbitol and xylitol but having no activity towards primary alcohols.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NB100-1486	Applications	Species
Sanchez-Lozada LG, Andres-Hernando A, Garcia-Arroyo FE et al. Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats. J. Biol. Chem. 2019-01-16 [PMID: 30651350] (WB, Human)	WB	Human
Cao W, Aghajanian HK, Haig-Ladewig LA, Gerton GL. Sorbitol can fuel mouse sperm motility and protein tyrosine phosphorylation via sorbitol dehydrogenase. Biol Reprod. 2009-01-01 [PMID: 18799757] (WB, Mouse) Details: WB (mouse sperm cells), Fig. 1A,B,C; Sup. Fig. 2.	WB	Mouse
Karacaoglan V, Ozer I. Steady-state kinetic properties of sorbitol dehydrogenase from chicken liver. Comp Biochem Physiol B Biochem Mol Biol 2005-02-01 [PMID: 15649778]

Array NB100-1486

• Sorbitol Dehydrogenase Antibodies
• Sorbitol Dehydrogenase ELISA Kits
• Sorbitol Dehydrogenase Lysate
• Sorbitol Dehydrogenase Proteins