SETD8 Antibody [PerCP]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF (-), IHC (-)
Clonality
Polyclonal
Host
Rabbit
Conjugate
PerCP

Order Details

SETD8 Antibody [PerCP] Summary

Immunogen
A synthetic peptide made to an internal portion of the human SETD8 protein (between residues 100-200) [UniProt Q9NQR1]
Localization
Nucleus. Chromosome. Note: Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KMT5A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for SETD8 Antibody [PerCP]

  • H4-K20-HMTase KMT5A
  • H4-K20-HMTase SETD8
  • H4K20-specific histone methyltransferase splice variant Set8b
  • Histone-lysine N-methyltransferase SETD8
  • KMT5A SET domain-containing protein 8
  • KMT5A
  • Lysine N-methyltransferase 5A
  • PR/SET domain containing protein 8
  • PR/SET domain-containing protein 07
  • PR/SET07
  • PRSET7
  • PR-Set7
  • PR-Set7EC 2.1.1.43
  • SET domain containing (lysine methyltransferase) 8
  • SET07
  • SET07SET8H4-K20-specific histone methyltransferase
  • SET8
  • SETD8

Background

Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20'monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression.Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNAduring mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substratecompared to free histones

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Research Areas for SETD8 Antibody (NBP1-91269PCP)

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Blogs on SETD8

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Bioinformatics

Gene Symbol KMT5A