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SDHB Antibody (SDHB/2126) [Janelia Fluor® 525]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clone
SDHB/2126
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 525

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-08809AF350
Alexa Fluor 405
NBP3-08809AF405
Alexa Fluor 488
NBP3-08809AF488
Alexa Fluor 532
NBP3-08809AF532
Alexa Fluor 594
NBP3-08809AF594
Alexa Fluor 647
NBP3-08809AF647
Alexa Fluor 700
NBP3-08809AF700
Alexa Fluor 750
NBP3-08809AF750
Allophycocyanin
NBP3-08809APC
Biotin
NBP3-08809B
CoraFluor 1
NBP3-08809CL1
DyLight 350
NBP3-08809UV
DyLight 405
NBP3-08809V
DyLight 488
NBP3-08809G
DyLight 550
NBP3-08809R
DyLight 594
NBP3-08809DL594
DyLight 650
NBP3-08809C
DyLight 680
NBP3-08809FR
DyLight 755
NBP3-08809IR
FITC
NBP3-08809F
HRP
NBP3-08809H
Janelia Fluor 549
NBP3-08809JF549
Janelia Fluor 585
NBP3-08809JF585
Janelia Fluor 635
NBP3-08809JF635
Janelia Fluor 646
NBP3-08809JF646
Janelia Fluor 669
NBP3-08809JF669
PE
NBP3-08809PE
PerCP
NBP3-08809PCP
Unconjugated
NBP3-07786-100ug
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP3-07786-100ug
Azide and BSA Free
NBP3-08809
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SDHB Antibody (SDHB/2126) [Janelia Fluor® 525] Summary

Immunogen
Recombinant human SDHB fragment around aa 165-273 (Exact sequence is proprietary) (Uniprot: P21912 )
Localization
Cytoplasmic (Mitochondria)
Marker
Pheochromocytoma Marker
Specificity
Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation. Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
SDHB
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Others not known.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for SDHB Antibody (SDHB/2126) [Janelia Fluor® 525]

  • EC 1.3.5.1
  • FLJ92337
  • IP
  • Iron-sulfur subunit of complex II
  • PGL4
  • SDH
  • SDH1
  • SDH2
  • SDHIP
  • succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Background

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SDHB