SARS Nucleocapsid Protein Antibody

It has recently been shown that SARS is caused by a human coronavirus. Human coronaviruses are the major cause of upper respiratory tract illness in humans, such as the common cold. Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). The first step in coronavirus infection is binding of the viral spike protein, a 139-kDa protein, to certain receptors on host cells. The spike protein is the main surface antigen of the coronavirus. The most prominent protein in the culture supernatants infected with SARS virus is a 46 kDa nucleocapsid protein. This suggests that the nucleocapsid protein is a major immunogen that may be useful for early diagnostics.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using NB100-56049	Applications	Species
Cameron A, Porterfield CA, Byron LD et al. A Multiplex Microsphere IgG Assay for SARS-CoV-2 Using ACE2-Mediated Inhibition as a Surrogate for Neutralization Journal of Clinical Microbiology 2021-01-21 [PMID: 33139422]
Zhang L, Wei L, Jiang D et al. SARS-CoV nucleocapsid protein induced apoptosis of COS-1 mediated by the mitochondrial pathway. Artif Cells Blood Substit Immobil Biotechnol. 2007-01-01 [PMID: 17453707] Details: WB: Fig. 1 (COS-1, Huh-7, and Hep2 transiently or mock-transfected with SARS Matrix, Spike, or Nucleocapsid proteins), Antibodies were transfected validated. Imgenex products cited: 1. SARS-Spike (IMG-5119A) 2. SARS-Spike (IMG-5015) 3. SARS-M (IMG-5125A).
Ren Lili, Yang Renquan, Guo Li et al. Apoptosis induced by the SARS-associated coronavirus in Vero cells is replication-dependent and involves caspase. DNA Cell Biol. 2005-08-01 [PMID: 16101347]

Array NB100-56049

• SARS Nucleocapsid Protein Antibodies
• SARS Nucleocapsid Protein Antibody Pack
• SARS Nucleocapsid Protein Proteins