Recombinant Rat Reg3A Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Reg3A (Regenerating islet-derived protein 3 alpha), also known as Reg III-alpha , PAP2 (pancreatitis-associated protein 2), and Lithostathine 3 in rats, or HIP/PAP (human islet peptide/PAP) in humans, is a secreted 16-17 kDa type III member of the Reg family, which is the group 7 subfamily of C-type lectins (1, 2). The four type III genes ( alpha -δ) in the rat Reg family are thought to have cell-protective and proliferative effects (2-4). Like other Reg proteins, the 149 amino acid (aa) mature rat mouse Reg3A (aa 26‑174) contains a small, trypsin-cleavable PAP domain (aa 26-36) and a C-type lectin domain (2, 5).  Mature rat Reg3A shares 82% and 58% aa sequence identity with mouse and human Reg3A, (also called HIP/PAP) respectively. Rodent Reg3A is mainly expressed in the intestinal tract and the exocrine pancreas by acinar cells and islet alpha  cells;, and it is up-regulated by IL-6 enhances expression (1, 3, 6, 7). Pancreatic Reg3A expression is also increased in mouse models of type 1 diabetes (4). In the rat brain, nerve injury and inflammation increase Reg3A expression in dorsal root ganglion neurons, while low dopamine levels duringin stress induce its production by melanocytes (8, 9). Treatment of rat macrophages with Reg3A causes up-regulation of NFkB signaling and modulation of cytokine production (2, 10). In humans, Reg3A expression and proteolytic activation in the small intestine areis thought to have a protective effect against infection and TNF-alpha -induced stress (11).

Array 8347-RG

• Reg3A Antibodies
• Reg3A ELISA Kits
• Reg3A Lysates
• Reg3A Proteins
• Reg3A ELISA
• Reg3A Proteins and Enzymes