Recombinant Mouse NPRA/NPR1 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Mouse Natriuretic Peptide Receptor-1 (NPR1), also known as NPRA, ANP-R1 or guanlyl cyclase-A, is a 130 kDa member of the guanylyl cyclase family of proteins. NPR1 is a type I transmembrane glycoprotein that contains a 441 amino acid extracellular domain (ECD) (aa 29‑469) for ligand binding, and a 567 amino acid cytoplasmic region that contains both a protein kinase domain and a guanylate cyclase domain. NPR1 is expressed most highly in kidney, adrenal and adipose tissue (1). NPR1 operates as an oligomer and binds both ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide). Binding of ANP to the extracellular ligand binding domain, plus ATP to the intracellular kinase domain activates a cytoplasmic guanylate cyclase (1). This process induces bronchodilation and a reduction in blood pressure (2). Over the extracellular domain, mouse NPR1 is 97% and 86% identical to rat and human NPR1, respectively.

Array 9726-NR

• NPRA/NPR1 Antibodies
• NPRA/NPR1 Lysate
• NPRA/NPR1 Proteins
• NPRA/NPR1 Proteins and Enzyme