Recombinant Mouse DR6/TNFRSF21 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Death Receptor 6 (DR6), also known as TNFRSF21 and CD358, is a type I transmembrane protein in the TNF receptor superfamily (1). Mouse DR6 consists of a 308 amino acid (aa) extracellular domain (ECD) with four cysteine-rich motifs, a 21 aa transmembrane segment, and a 285 aa palmityolated cytoplasmic region that contains one death domain (2, 3). Within the ECD, mouse and human DR6 share 82% aa sequence identity. DR6 is expressed as an approximately 110 kDa molecule that carries extensive N-linked and O-linked glycosylation in its extracellular region (3, 4). Among hematopoietic cells, DR6 is expressed on monocytes, resting CD4+ T cells, and pro-, pre-, and naïve B cells (5 - 7). DR6 knockout mice exhibit a Th2-biased immune response characterized by exaggerated Th2 and B cell responsiveness in combination with reduced Th1 cell responsiveness and inflammatory leukocyte infiltration (2, 6 - 8). DR6 knockout mice are resistant to induced airway inflammation and experimental autoimmune encephalitis but more susceptible to severe graft versus host disease (8 - 10). DR6 is also expressed on developing neurons where it can bind a shed 35 kDa N-terminal fragment of APP or a fragment of APLP2 (11, 12). This APP fragment is generated following deprivation of neurotrophic factors, and its binding to DR6 triggers DR6-mediated axonal pruning (11). DR6 is constitutively expressed on some prostate cancer cells and can be induced by TNF-alpha on others (3, 4).

Array 6985-DR

• DR6/TNFRSF21 Antibodies
• DR6/TNFRSF21 Lysate
• DR6/TNFRSF21 Proteins and Enzymes